7 results on '"Lenglet T"'
Search Results
2. Assessing the upper motor neuron in amyotrophic lateral sclerosis using the triple stimulation technique: A multicenter prospective study.
- Author
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Grapperon AM, Verschueren A, Jouve E, Morizot-Koutlidis R, Lenglet T, Pradat PF, Salachas F, Bernard E, Delstanche S, Maertens de Noordhout A, Guy N, Danel V, Delval A, Delmont E, Rolland AS, Pulse Study Group, Jomir L, Devos D, Wang F, and Attarian S
- Subjects
- Aged, Electric Stimulation methods, Female, Humans, Male, Middle Aged, Motor Neuron Disease diagnosis, Motor Neuron Disease physiopathology, Prospective Studies, Amyotrophic Lateral Sclerosis diagnosis, Amyotrophic Lateral Sclerosis physiopathology, Evoked Potentials, Motor physiology, Motor Neurons physiology, Transcranial Magnetic Stimulation methods, Ulnar Nerve physiology
- Abstract
Objective: To evaluate the relevance of transcranial magnetic stimulation (TMS) using triple stimulation technique (TST) to assess corticospinal function in amyotrophic lateral sclerosis (ALS) in a large-scale multicenter study., Methods: Six ALS centers performed TST and conventional TMS in upper limbs in 98 ALS patients during their first visit to the center. Clinical evaluation of patients included the revised ALS Functional Rating Scale (ALSFRS-R) and upper motor neuron (UMN) score., Results: TST amplitude ratio was decreased in 62% of patients whereas conventional TMS amplitude ratio was decreased in 25% of patients and central motor conduction time was increased in 16% of patients. TST amplitude ratio was correlated with ALSFRS-R and UMN score. TST amplitude ratio results were not different between the centers., Conclusions: TST is a TMS technique applicable in daily clinical practice in ALS centers for the detection of UMN dysfunction, more sensitive than conventional TMS and related to the clinical condition of the patients., Significance: This multicenter study shows that TST can be a routine clinical tool to evaluate UMN dysfunction at the diagnostic assessment of ALS patients., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
3. Motor unit number index as an individual biomarker: Reference limits of intra-individual variability over time in healthy subjects.
- Author
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Delmont E, Wang F, Lefaucheur JP, Puma A, Breniere C, Beaudonnet G, Cintas P, Collin R, Fortanier E, Grapperon AM, Jomir L, Kribich H, Kouton L, Kuntzer T, Lenglet T, Magot A, Nordine T, Ochsner F, Bolloy G, Pereon Y, Salort-Campana E, Tard C, Vicino A, Verschueren A, and Attarian S
- Subjects
- Adult, Aged, Electromyography methods, Female, Healthy Volunteers, Humans, Male, Middle Aged, Neuromuscular Diseases diagnosis, Neuromuscular Diseases physiopathology, Reproducibility of Results, Young Adult, Motor Neurons physiology, Muscle, Skeletal physiology, Recruitment, Neurophysiological physiology
- Abstract
Objective: Motor unit number index (MUNIX) is proposed to monitor neuromuscular disorders. Our objective is to determine the intra-individual variability over time of the MUNIX., Methods: In 11 different hospital centres, MUNIX was assessed twice, at least 3 months apart (range 90-360 days), in tibialis anterior (TA), abductor pollicis brevis (APB), abductor digiti minimi (ADM) and deltoid muscles in 118 healthy subjects. MUNIX sum score 2, 3 and 4 were respectively the sum of the MUNIX of the TA and ADM, of the TA, APB and ADM and of the TA, APB, ADM and deltoid muscles., Results: The repeatability of the MUNIX was better for sum scores than for single muscle recordings. The variability of the MUNIX was independent of sex, age, interval between measurements and was lower for experienced than non-experienced operators. The 95th percentile of the coefficient of variability of the MUNIX sum score 2, 3 and 4 were respectively 22%, 18% and 15% for experienced operators., Conclusions: The MUNIX technique must be performed by experienced operators on several muscles to reduce its variability and improve its reliability., Significance: A variation of the MUNIX sum score ≥20% can be interpreted as a significant change of muscle innervation., Competing Interests: Declaration of Competing Interest Authors don’t have potential conflicts of interest to be disclosed., (Copyright © 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
4. Assessment of the reliability of the motor unit size index (MUSIX) in single subject "round-robin" and multi-centre settings.
- Author
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Alix JJP, Neuwirth C, Gelder L, Burkhardt C, Castro J, de Carvalho M, Gawel M, Goedee S, Grosskreutz J, Lenglet T, Moglia C, Omer T, Schrooten M, Nandedkar S, Stalberg E, Barkhaus PE, Furtula J, van Dijk JP, Baldinger R, Costa J, Otto M, Sandberg A, and Weber M
- Subjects
- Amyotrophic Lateral Sclerosis physiopathology, Electromyography, Female, Healthy Volunteers, Humans, Male, Muscle, Skeletal physiopathology, Neuromuscular Diseases physiopathology, Reproducibility of Results, Motor Neurons physiology, Muscle, Skeletal physiology
- Abstract
Objective: The motor unit size index (MUSIX) is incorporated into the motor unit number index (MUNIX). Our objective was to assess the intra-/inter-rater reliability of MUSIX in healthy volunteers across single subject "round robin" and multi-centre settings., Methods: Data were obtained from (i) a round-robin assessment in which 12 raters (6 with prior experience and 6 without) assessed six muscles (abductor pollicis brevis, abductor digiti minimi, biceps brachii, tibialis anterior, extensor digitorum brevis and abductor hallucis) and (ii) a multi-centre study with 6 centres studying the same muscles in 66 healthy volunteers. Intra/inter-rater data were provided by 5 centres, 1 centre provided only intra-rater data. Intra/inter-rater variability was assessed using the coefficient of variation (COV), Bland-Altman plots, bias and 95% limits of agreement., Results: In the round-robin assessment intra-rater COVs for MUSIX ranged from 7.8% to 28.4%. Inter-rater variability was between 7.8% and 16.2%. Prior experience did not impact on MUSIX values. In the multi-centre study MUSIX was more consistent than the MUNIX. Abductor hallucis was the least reliable muscle., Conclusions: The MUSIX is a reliable neurophysiological biomarker of reinnervation., Significance: MUSIX could provide insights into the pathophysiology of a range of neuromuscular disorders, providing a quantitative biomarker of reinnervation., (Copyright © 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
- Published
- 2019
- Full Text
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5. Neuropathic pain, dysautonomia, and nerve hyperexcitability: Expanding the spectrum of LGI1 autoimmunity.
- Author
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Berzero G, Lenglet T, Giry M, d'Anglejan J, Joubert B, Cohen F, and Psimaras D
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- Adult, Autoantibodies immunology, Humans, Intracellular Signaling Peptides and Proteins, Male, Motor Neurons physiology, Neuralgia complications, Neuralgia diagnosis, Primary Dysautonomias complications, Primary Dysautonomias diagnosis, Proteins immunology, Autoantibodies blood, Autoimmunity physiology, Neuralgia blood, Primary Dysautonomias blood, Proteins metabolism
- Published
- 2019
- Full Text
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6. The motor unit number index (MUNIX) profile of patients with adult spinal muscular atrophy.
- Author
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Querin G, Lenglet T, Debs R, Stojkovic T, Behin A, Salachas F, Le Forestier N, Amador MDM, Lacomblez L, Meininger V, Bruneteau G, Laforêt P, Blancho S, Marchand-Pauvert V, Bede P, Hogrel JY, and Pradat PF
- Subjects
- Adult, Disability Evaluation, Female, Humans, Male, Middle Aged, Muscle Strength, Muscle, Skeletal innervation, Muscle, Skeletal physiopathology, Recruitment, Neurophysiological, Spinal Muscular Atrophies of Childhood pathology
- Abstract
Objective: Objective of this study is the comprehensive characterisation of motor unit (MU) loss in type III and IV Spinal Muscular Atrophy (SMA) using motor unit number index (MUNIX), and evaluation of compensatory mechanisms based on MU size indices (MUSIX)., Methods: Nineteen type III and IV SMA patients and 16 gender- and age-matched healthy controls were recruited. Neuromuscular performance was evaluated by muscle strength testing and functional scales. Compound motor action potential (CMAP), MUNIX and MUSIX were studied in the abductor pollicis brevis (APB), abductor digiti minimi (ADM), deltoid, tibialis anterior and trapezius muscles. A composite MUNIX score was also calculated., Results: SMA patients exhibited significantly reduced MUNIX values (p < 0.05) in all muscles, while MUSIX was increased, suggesting active re-innervation. Significant correlations were identified between MUNIX/MUSIX and muscle strength. Similarly, composite MUNIX scores correlated with disability scores. Interestingly, in SMA patients MUNIX was much lower in the ADM than in the ABP, a pattern which is distinctly different from that observed in Amyotrophic Lateral Sclerosis., Conclusions: MUNIX is a sensitive measure of MU loss in adult forms of SMA and correlates with disability., Significance: MUNIX evaluation is a promising candidate biomarker for longitudinal studies and pharmacological trials in adult SMA patients., (Copyright © 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
7. Implementing Motor Unit Number Index (MUNIX) in a large clinical trial: Real world experience from 27 centres.
- Author
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Neuwirth C, Braun N, Claeys KG, Bucelli R, Fournier C, Bromberg M, Petri S, Goedee S, Lenglet T, Leppanen R, Canosa A, Goodman I, Al-Lozi M, Ohkubo T, Hübers A, Atassi N, Abrahao A, Funke A, Appelfeller M, Tümmler A, Finegan E, Glass JD, Babu S, Ladha SS, Kwast-Rabben O, Juntas-Morales R, Coffey A, Chaudhry V, Vu T, Saephanh C, Newhard C, Zakrzewski M, Rosier E, Hamel N, Raheja D, Raaijman J, Ferguson T, and Weber M
- Subjects
- Amyotrophic Lateral Sclerosis epidemiology, Female, Humans, Longitudinal Studies, Male, Amyotrophic Lateral Sclerosis diagnosis, Amyotrophic Lateral Sclerosis physiopathology, Recruitment, Neurophysiological physiology
- Abstract
Objective: Motor Unit Number Index (MUNIX) is a quantitative neurophysiological method that reflects loss of motor neurons in Amyotrophic Lateral Sclerosis (ALS) in longitudinal studies. It has been utilized in one natural history ALS study and one drug trial (Biogen USA) after training and qualification of raters., Methods: Prior to testing patients, evaluators had to submit test-retest data of 4 healthy volunteers. Twenty-seven centres with 36 raters measured MUNIX in 4 sets of 6 different muscles twice. Coefficient of variation of all measurements had to be <20% to pass the qualification process. MUNIX COV of the first attempt, number of repeated measurements and muscle specific COV were evaluated., Results: COV varied considerably between raters. Mean COV of all raters at the first measurements was 12.9% ± 13.5 (median 8.7%). Need of repetitions ranged from 0 to 43 (mean 10.7 ± 9.1, median 8). Biceps and first dorsal interosseus muscles showed highest repetition rates. MUNIX variability correlated considerably with variability of compound muscle action potential., Conclusion: MUNIX revealed generally good reliability, but was rater dependent and ongoing support for raters was needed., Significance: MUNIX can be implemented in large clinical trials as an outcome measure after training and a qualification process., (Copyright © 2018 International Federation of Clinical Neurophysiology. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
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