1. The presence of erythropoietin receptors in the human peripheral nervous system
- Author
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Kamal Hassan, Kristal B, Shasha Sm, Cohen H, Gross B, Rubinchik I, Jeanna Jacobi, and Simri W
- Subjects
Nervous system ,medicine.medical_specialty ,Cell type ,Pathology ,Central nervous system ,hemic and lymphatic diseases ,Internal medicine ,Receptors, Erythropoietin ,medicine ,Humans ,Receptor ,Myelin Sheath ,business.industry ,Vagus Nerve ,General Medicine ,medicine.disease ,Neuroregeneration ,Spinal Nerves ,Endocrinology ,medicine.anatomical_structure ,Nephrology ,Erythropoietin ,Peripheral nervous system ,business ,Polyneuropathy ,medicine.drug - Abstract
Erythropoietin (EPO) is a well-known hematopoietic factor and a major determinant of tissue oxygenation. EPO receptors have been identified on a wide variety of non-erythroid cell types including human central nervous system and peripheral nervous system of animal models. The presence or function of EPO receptors in human peripheral nervous system is unknown. By examining nerve segments from radicular and autonomic nerves using immunohistochemical methods, we demonstrated the presence of EPO receptors on myelin sheath of radicular nerves in the human peripheral nervous system.
- Published
- 2004