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Start Over Author "Yahav, Dafna" Journal clinical microbiology and infection
26 results on '"Yahav, Dafna"'

1. Universal Risk Factors for Mortality in Bloodstream Infections (UNIFORM): a systematic review and Delphi survey

Author

Bonten, Marc, Carmeli, Yehuda, Carrara, Elena, Chambers, Henry F., Davis, Joshua S., Daikos, George L., de Kraker, Marlieke, Durante-Mangoni, Emanuele, Huttner, Angela, Kalil, Andre C., Kaye, Keith, Lee, Todd C., Leibovici, Leonard, Palacios-Baena, Zaira R., Paterson, David, Paul, Mical, Gentil, Pilar Retamar, Baño, Jesus Rodríiguez, Scudeller, Luigia, Tacconelli, Evelina, Thwaites, Guy, Tong, Steven, Varon, Ben, Yahav, Dafna, de Kraker, Marlieke E.A., and Rodríguez-Baño, Jesús

Published
2024
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5. In vivo fitness of carbapenem-resistant Acinetobacter baumannii strains in murine infection is associated with treatment failure in human infections

Author

Paul, Mical, Benattar, Yael Dishon, Dickstein, Yaakov, Bitterman, Roni, Zayyad, Hiba, Koppel, Fidi, Zak-Doron, Yael, Altunin, Sergey, Andria, Nizar, Neuberger, Ami, Stern, Anat, Petersiel, Neta, Raines, Marina, Karban, Amir, Leibovici, Leonard, Yahav, Dafna, Eliakim-Raz, Noa, Zusman, Oren, Elbaz, Michal, Atamna, Heyam, Daitch, Vered, Babich, Tanya, Carmeli, Yehuda, Nutman, Amir, Adler, Amos, Levi, Inbar, Daikos, George L., Skiada, Anna, Pavleas, Ioannis, Antoniadou, Anastasia, Kotsaki, Antigoni, Durante-Mangoni, Emanuele, Andini, Roberto, Iossa, Domenico, Bernardo, Mariano, Cavezza, Giusi, Bertolino, Lorenzo, Giuffre, Giuseppe, Giurazza, Roberto, Ruocco, Giuseppe, Galdo, Maria, Murino, Patrizia, Cristinziano, Adriano, Corcione, Antonio, Zampino, Rosa, Mouton, Johan, Friberg, Lena, Theuretzbacher, Ursula, Temkin, Elizabeth, Lellouche, Jonathan, Rakovitsky, Nadya, Hameir, Amichay, Daikos, George, Dishon, Yael, Eliakim, Noa, and Friberg, Lena E.

Published
2022
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7. Universal Risk Factors for Mortality in Bloodstream Infections (UNIFORM): a systematic review and Delphi survey

Author

Varon, Ben, primary, Palacios-Baena, Zaira R., additional, de Kraker, Marlieke E.A., additional, Rodríguez-Baño, Jesús, additional, Leibovici, Leonard, additional, Paul, Mical, additional, Bonten, Marc, additional, Carmeli, Yehuda, additional, Carrara, Elena, additional, Chambers, Henry F., additional, Davis, Joshua S., additional, Daikos, George L., additional, Kraker, Marlieke de, additional, Durante-Mangoni, Emanuele, additional, Huttner, Angela, additional, Kalil, Andre C., additional, Kaye, Keith, additional, Lee, Todd C., additional, Paterson, David, additional, Gentil, Pilar Retamar, additional, Baño, Jesus Rodríiguez, additional, Scudeller, Luigia, additional, Tacconelli, Evelina, additional, Thwaites, Guy, additional, Tong, Steven, additional, Varon, Ben, additional, and Yahav, Dafna, additional

Published
2024
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9. Colistin plus meropenem for carbapenem-resistant Gram-negative infections: in vitro synergism is not associated with better clinical outcomes

Author

Paul, Mical, Benattar, Yael Dishon, Dickstein, Yaakov, Bitterman, Roni, Zayyad, Hiba, Koppel, Fidi, Zak-Doron, Yael, Altunin, Sergey, Andria, Nizar, Neuberger, Ami, Stern, Anat, Petersiel, Neta, Raines, Marina, Karban, Amir, Leibovici, Leonard, Yahav, Dafna, Eliakim-Raz, Noa, Zusman, Oren, Elbaz, Michal, Atamna, Heyam, Daitch, Vered, Babich, Tanya, Carmeli, Yehuda, Nutman, Amir, Adler, Amos, Levi, Inbar, Daikos, George L., Skiada, Anna, Pavleas, Ioannis, Antoniadou, Anastasia, Kotsaki, Antigoni, Durante-Mangoni, Emanuele, Andini, Roberto, Iossa, Domenico, Bernardo, Mariano, Cavezza, Giusi, Bertolino, Lorenzo, Giuffre, Giuseppe, Giurazza, Roberto, Cuccurullo, Susanna, Galdo, Maria, Murino, Patrizia, Cristinziano, Adriano, Corcione, Antonio, Zampino, Rosa, Pafundi, Pia Clara, Mouton, Johan, Friberg, Lena, Kristoffersson, Anders, Theuretzbacher, Ursula, Lellouche, Jonathan, Temkin, Elizabeth, Daikos, George, Dishon-Benattar, Yael, Friberg, Lena E., and Mouton, Johan W.

Published
2020
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19. In vivo fitness of carbapenem-resistant Acinetobacter baumannii strains in murine infection is associated with treatment failure in human infections

Author

Nutman, Amir, primary, Temkin, Elizabeth, additional, Lellouche, Jonathan, additional, Rakovitsky, Nadya, additional, Hameir, Amichay, additional, Daikos, George, additional, Durante-Mangoni, Emanuele, additional, Pavleas, Ioannis, additional, Dishon, Yael, additional, Petersiel, Neta, additional, Yahav, Dafna, additional, Eliakim, Noa, additional, Bernardo, Mariano, additional, Iossa, Domenico, additional, Friberg, Lena E., additional, Theuretzbacher, Ursula, additional, Leibovici, Leonard, additional, Paul, Mical, additional, Carmeli, Yehuda, additional, Benattar, Yael Dishon, additional, Dickstein, Yaakov, additional, Bitterman, Roni, additional, Zayyad, Hiba, additional, Koppel, Fidi, additional, Zak-Doron, Yael, additional, Altunin, Sergey, additional, Andria, Nizar, additional, Neuberger, Ami, additional, Stern, Anat, additional, Raines, Marina, additional, Karban, Amir, additional, Eliakim-Raz, Noa, additional, Zusman, Oren, additional, Elbaz, Michal, additional, Atamna, Heyam, additional, Daitch, Vered, additional, Babich, Tanya, additional, Nutman, Amir, additional, Adler, Amos, additional, Levi, Inbar, additional, Daikos, George L., additional, Skiada, Anna, additional, Antoniadou, Anastasia, additional, Kotsaki, Antigoni, additional, Andini, Roberto, additional, Cavezza, Giusi, additional, Bertolino, Lorenzo, additional, Giuffre, Giuseppe, additional, Giurazza, Roberto, additional, Ruocco, Giuseppe, additional, Galdo, Maria, additional, Murino, Patrizia, additional, Cristinziano, Adriano, additional, Corcione, Antonio, additional, Zampino, Rosa, additional, Mouton, Johan, additional, and Friberg, Lena, additional

Published
2022
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25. Colistin plus meropenem for carbapenem-resistant Gram-negative infections: in vitro synergism is not associated with better clinical outcomes

Author

Nutman, Amir, primary, Lellouche, Jonathan, additional, Temkin, Elizabeth, additional, Daikos, George, additional, Skiada, Anna, additional, Durante-Mangoni, Emanuele, additional, Dishon-Benattar, Yael, additional, Bitterman, Roni, additional, Yahav, Dafna, additional, Daitch, Vered, additional, Bernardo, Mariano, additional, Iossa, Domenico, additional, Zusman, Oren, additional, Friberg, Lena E., additional, Mouton, Johan W., additional, Theuretzbacher, Ursula, additional, Leibovici, Leonard, additional, Paul, Mical, additional, Carmeli, Yehuda, additional, Benattar, Yael Dishon, additional, Dickstein, Yaakov, additional, Zayyad, Hiba, additional, Koppel, Fidi, additional, Zak-Doron, Yael, additional, Altunin, Sergey, additional, Andria, Nizar, additional, Neuberger, Ami, additional, Stern, Anat, additional, Petersiel, Neta, additional, Raines, Marina, additional, Karban, Amir, additional, Eliakim-Raz, Noa, additional, Elbaz, Michal, additional, Atamna, Heyam, additional, Babich, Tanya, additional, Nutman, Amir, additional, Adler, Amos, additional, Levi, Inbar, additional, Daikos, George L., additional, Pavleas, Ioannis, additional, Antoniadou, Anastasia, additional, Kotsaki, Antigoni, additional, Andini, Roberto, additional, Cavezza, Giusi, additional, Bertolino, Lorenzo, additional, Giuffre, Giuseppe, additional, Giurazza, Roberto, additional, Cuccurullo, Susanna, additional, Galdo, Maria, additional, Murino, Patrizia, additional, Cristinziano, Adriano, additional, Corcione, Antonio, additional, Zampino, Rosa, additional, Pafundi, Pia Clara, additional, Mouton, Johan, additional, Friberg, Lena, additional, and Kristoffersson, Anders, additional

Published
2020
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26. In vivo fitness of carbapenem-resistant Acinetobacter baumannii strains in murine infection is associated with treatment failure in human infections

Author

Nizar Andria, Anat Stern, Nadya Rakovitsky, Lena E. Friberg, Rosa Zampino, Amos Adler, Yael Zak-Doron, Yehuda Carmeli, Patrizia Murino, Noa Eliakim, Roni Bitterman, Lorenzo Bertolino, Giuseppe Giuffre, Jonathan Lellouche, Mariano Bernardo, Antonio Corcione, Antigoni Kotsaki, Hiba Zayyad, Anastasia Antoniadou, Johan W. Mouton, Tanya Babich, Neta Petersiel, Amir Karban, Domenico Iossa, Giuseppe Ruocco, Vered Daitch, Ami Neuberger, Oren Zusman, George L. Daikos, Sergey Altunin, Roberto Giurazza, Noa Eliakim-Raz, Ursula Theuretzbacher, Yael Dishon, Mical Paul, Emanuele Durante-Mangoni, Yael Dishon Benattar, Dafna Yahav, Leonard Leibovici, Anna Skiada, Inbar Levi, Michal Elbaz, Giusi Cavezza, Heyam Atamna, Elizabeth Temkin, Amichay Hameir, Amir Nutman, Yaakov Dickstein, Marina Raines, Roberto Andini, Fidi Koppel, Maria Galdo, Ioannis Pavleas, Adriano Cristinziano, Nutman, Amir, Temkin, Elizabeth, Lellouche, Jonathan, Rakovitsky, Nadya, Hameir, Amichay, Daikos, George, Durante-Mangoni, Emanuele, Pavleas, Ioanni, Dishon, Yael, Petersiel, Neta, Yahav, Dafna, Eliakim, Noa, Bernardo, Mariano, Iossa, Domenico, Friberg, Lena E, Theuretzbacher, Ursula, Leibovici, Leonard, Paul, Mical, and Carmeli, Yehuda

Subjects
Acinetobacter baumannii, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, animal structures, Urinary system, 030106 microbiology, Microbial Sensitivity Tests, Logistic regression, law.invention, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, law, Internal medicine, Drug Resistance, Bacterial, medicine, Animals, Humans, Treatment Failure, 030212 general & internal medicine, biology, Bacterial fitne, Clinical outcome, business.industry, food and beverages, General Medicine, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, medicine.disease, biology.organism_classification, Intensive care unit, Anti-Bacterial Agents, body regions, Pneumonia, Infectious Diseases, Carbapenems, Murine thigh infection model, Carbapenem-resistant Acinetobacter baumannii, SOFA score, business, Carbapenem resistant Acinetobacter baumannii, Acinetobacter Infections
Abstract

Objectives Mortality among patients with carbapenem-resistant Acinetobacter baumannii (CRAB) infections varies between studies. We examined whether in vivo fitness of CRAB strains is associated with clinical outcomes in patients with CRAB infections. Methods Isolates were collected from patients enrolled in the AIDA trial with hospital-acquired pneumonia, bloodstream infections and/or urinary tract infections caused by CRAB. The primary outcome was 14-day clinical failure, defined as failure to meet all criteria: alive; haemodynamically stable; improved or stable Sequential Organ Failure Assessment (SOFA) score; improved or stable oxygenation; and microbiological cure of bacteraemia. The secondary outcome was 14-day mortality. We tested in vivo growth using a neutropenic murine thigh infection model. Fitness was defined based on the CFU count 24 hours after injection of an inoculum of 105 CFU. We used mixed-effects logistic regression to test the association between fitness and the two outcomes. Results The sample included 266 patients; 215 (80.8%) experienced clinical failure. CRAB fitness ranged from 5.23 to 10.08 log CFU/g. The odds of clinical failure increased by 62% for every 1-log CFU/g increase in fitness (OR 1.62, 95% CI 1.04–2.52). After adjusting for age, Charlson score, SOFA score and acquisition in the intensive care unit, fitness remained significant (adjusted OR 1.63, 95% CI 1.03–2.59). CRAB fitness had a similar effect on 14-day mortailty, although the association was not statistically significant (OR 1.56, 95% CI 0.95–2.57). It became significant after adjusting for age, Charlson score, SOFA score and recent surgery (adjusted OR 1.88, 95% CI 1.09–3.25). Conclusions In vivo CRAB fitness was associated with clinical failure in patients with CRAB infection.

Published
2022

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