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19 results on '"Wang, Eunice S."'

1. POSTER: AML-303 Tagraxofusp, an Anti-CD123 Therapy, in Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm and Prior or Concomitant Hematologic Malignancies: Subgroup Analysis of a Pivotal Trial

Author

Pemmaraju, Naveen, primary, Konopleva, Marina, additional, Sweet, Kendra, additional, Stein, Anthony, additional, Vasu, Sumithira, additional, Rizzieri, David, additional, Wang, Eunice S., additional, Kantarjian, Hagop, additional, Brooks, Christopher, additional, Mughal, Tariq, additional, and Lane, Andrew A., additional

Published
2023
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2. AML-303 Tagraxofusp, an Anti-CD123 Therapy, in Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm and Prior or Concomitant Hematologic Malignancies: Subgroup Analysis of a Pivotal Trial

Author

Pemmaraju, Naveen, primary, Konopleva, Marina, additional, Sweet, Kendra, additional, Stein, Anthony, additional, Vasu, Sumithira, additional, Rizzieri, David, additional, Wang, Eunice S., additional, Kantarjian, Hagop, additional, Brooks, Christopher, additional, Mughal, Tariq, additional, and Lane, Andrew A., additional

Published
2023
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3. AML-262 Pivekimab Sunirine (PVEK, IMGN632) Triplet With Azacitidine and Venetoclax Shows Broad Activity in Adverse Genetic Subsets of Relapsed/Refractory Acute Myeloid Leukemia and Reduced Infusion-Related Reactions

Author

Daver, Naval, primary, Montesinos, Pau, additional, Aribi, Ahmed, additional, Martinelli, Giovanni, additional, Altman, Jessica K., additional, Wang, Eunice S., additional, Roboz, Gail J., additional, Burke, Patrick W., additional, Gaidano, Gianluca, additional, Walter, Roland B., additional, Thomas, Xavier, additional, Jeyakumar, Deepa, additional, DeAngelo, Daniel J., additional, Erba, Harry P., additional, Todisco, Elisabetta, additional, Begna, Kebede, additional, Advani, Anjali, additional, Gastaud, Lauris, additional, de la Fuente, Adolfo, additional, Curti, Antonio, additional, Mendez, Lourdes M., additional, Vyas, Paresh, additional, Boissel, Nicolas, additional, Vey, Norbert, additional, Recher, Christian, additional, Longval, Thomas, additional, Platzbecker, Uwe, additional, Kapp-Schwörer, Silke, additional, Schliemann, Christoph, additional, Konopleva, Marina, additional, Torres, Laura, additional, Sallman, David A., additional, Marcucci, Guido, additional, Marconi, Giovanni, additional, Kantarjian, Hagop, additional, Sloss, Callum M., additional, Malcolm, Karen E., additional, Zweidler-McKay, Patrick A., additional, and Sweet, Kendra, additional

Published
2022
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4. AML-397 Integrated Safety Analysis of Tagraxofusp, a CD123-Directed Targeted Therapy, in Patients With Hematologic Malignancies

Author

Pammaraju, Naveen, primary, Kantarjian, Hagop, additional, Sweet, Kendra, additional, Wang, Eunice S., additional, Lane, Andrew A., additional, Ali, Haris, additional, Stein, Anthony S., additional, Yacoub, Abdulraheem, additional, Rizzieri, David, additional, Vasu, Sumithira, additional, Gupta, Vikas, additional, Lee, Sangmin, additional, Schiller, Gary J., additional, Foran, James M., additional, Taparia, Minakshi S., additional, Rosenblat, Todd L., additional, Walter, Roland B., additional, Sieminski, Deborah, additional, Anant, Madhu, additional, Patnaik, Mrinal M., additional, Mughal, Tariq I., additional, and Konopleva, Marina, additional

Published
2022
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5. Poster: AML-397 Integrated Safety Analysis of Tagraxofusp, a CD123-Directed Targeted Therapy, in Patients With Hematologic Malignancies

Author

Pammaraju, Naveen, primary, Kantarjian, Hagop, additional, Sweet, Kendra, additional, Wang, Eunice S., additional, Lane, Andrew A., additional, Ali, Haris, additional, Stein, Anthony S., additional, Yacoub, Abdulraheem, additional, Rizzieri, David, additional, Vasu, Sumithira, additional, Gupta, Vikas, additional, Lee, Sangmin, additional, Schiller, Gary J., additional, Foran, James M., additional, Taparia, Minakshi S., additional, Rosenblat, Todd L., additional, Walter, Roland B., additional, Sieminski, Deborah, additional, Anant, Madhu, additional, Patnaik, Mrinal M., additional, Mughal, Tariq I., additional, and Konopleva, Marina, additional

Published
2022
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6. Poster: AML-262 Pivekimab Sunirine (PVEK, IMGN632) Triplet With Azacitidine and Venetoclax Shows Broad Activity in Adverse Genetic Subsets of Relapsed/Refractory Acute Myeloid Leukemia and Reduced Infusion-Related Reactions

Author

Daver, Naval, primary, Montesinos, Pau, additional, Aribi, Ahmed, additional, Martinelli, Giovanni, additional, Altman, Jessica K., additional, Wang, Eunice S., additional, Roboz, Gail J., additional, Burke, Patrick W., additional, Gaidano, Gianluca, additional, Walter, Roland B., additional, Thomas, Xavier, additional, Jeyakumar, Deepa, additional, DeAngelo, Daniel J., additional, Erba, Harry P., additional, Todisco, Elisabetta, additional, Begna, Kebede, additional, Advani, Anjali, additional, Gastaud, Lauris, additional, de la Fuente, Adolfo, additional, Curti, Antonio, additional, Mendez, Lourdes M., additional, Vyas, Paresh, additional, Boissel, Nicolas, additional, Vey, Norbert, additional, Recher, Christian, additional, Longval, Thomas, additional, Platzbecker, Uwe, additional, Kapp-Schwörer, Silke, additional, Schliemann, Christoph, additional, Konopleva, Marina, additional, Torres, Laura, additional, Sallman, David A., additional, Marcucci, Guido, additional, Marconi, Giovanni, additional, Kantarjian, Hagop, additional, Sloss, Callum M., additional, Malcolm, Karen E., additional, Zweidler-McKay, Patrick A., additional, and Sweet, Kendra, additional

Published
2022
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7. AML-465 Tagraxofusp, an Anti-CD123 Therapy, in Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm: Sub-Analysis of a Pivotal Trial by Age and Baseline Disease Involvement

Author

Pemmaraju, Naveen, primary, Konopleva, Marina, additional, Sweet, Kendra, additional, Stein, Anthony, additional, Vasu, Sumithira, additional, Rizzieri, David, additional, Wang, Eunice S., additional, Kantarjian, Hagop, additional, Brooks, Chris, additional, Mughal, Tariq, additional, and Lane, Andrew, additional

Published
2022
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9. Outcomes of Adult Acute Myeloid Leukemia Treated With Gemtuzumab-Ozogamicin: Cue To Optimized Chemotherapy Backbone

Author

Singh, Abhay, primary, Thota, Swapna, additional, Bradley, Terrence, additional, Griffiths, Elizabeth A., additional, Faber, Mark G., additional, Sadek, Sarah, additional, Przespolewski, Amanda, additional, Thompson, James E., additional, Baron, Jeffrey, additional, Cronin, Tara, additional, Attwood, Kristopher, additional, Madarang, Ellen Cvejanovich, additional, Watts, Justin, additional, and Wang, Eunice S., additional

Published
2021
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10. A Phase II Trial of Imatinib Mesylate as Maintenance Therapy for Patients With Newly Diagnosed C-kit–positive Acute Myeloid Leukemia

Author

Advani, Anjali S., primary, Tse, William, additional, Li, Hong, additional, Jia, Xuefei, additional, Elson, Paul, additional, Cooper, Brenda, additional, Ali-Osman, Francis, additional, Park, Jino, additional, Rao, Arati V., additional, Rizzieri, David A., additional, Wang, Eunice S., additional, Cotta, Claudiu V., additional, Kalaycio, Matt, additional, Sobecks, Ronald M., additional, Rouphail, Basel, additional, Maciejewski, Jaroslaw P., additional, Fensterl, Jaime, additional, Carew, Jennifer S., additional, Foster, Bethany, additional, Rush, Mary Lynn, additional, Tripp, Barbara, additional, Adams, Donna, additional, Corrigan, Donna, additional, Griffiths, Elizabeth A., additional, and Sekeres, Mikkael A., additional

Published
2021
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11. AML-140: Effect of Early Blood Counts on Response and Overall Survival Following Glasdegib Plus LDAC in Newly Diagnosed AML: BRIGHT AML 1003 Post Hoc Analysis

Author

Wang, Eunice S, primary, Heuser, Michael, additional, Sekeres, Mikkael A, additional, Papayannidis, Cristina, additional, Candoni, Anna, additional, Merchant, Akil, additional, Brown, Andrew M, additional, O'Connell, Ashleigh, additional, Ma, Weidong Wendy, additional, Chan, Geoffrey, additional, and Cortes, Jorge E, additional

Published
2020
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12. Glasdegib with LDAC in Newly Diagnosed Patients with Acute Myeloid Leukemia (AML) Unsuitable for Intensive Chemotherapy: Effects on Transfusions and Marrow Recovery vs LDAC Alone

Author

Wang, Eunice S., primary, Heuser, Michael, additional, Montesinos, Pau, additional, Sekeres, Mikkael A., additional, Merchant, Akil, additional, Olive, Carmen Pedro, additional, Salamero, Olga, additional, McCloskey, James K., additional, Hoang, Caroline J., additional, Ma, Weidong Wendy, additional, Zeremski, Mirjana, additional, O’Connell, Ashleigh, additional, Chan, Geoffrey, additional, and Cortes, Jorge E., additional

Published
2019
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13. Heterogeneous effects of targeting WNT signaling in AML blasts

Author

Srivastava, Pragya, primary, Griffiths, Elizabeth A., additional, Golding, Michelle C., additional, Povinelli, Benjamin J., additional, James, Smitha R., additional, Ford, Laurie A., additional, Wetzler, Meir, additional, Wang, Eunice S., additional, and Nemeth, Michael J., additional

Published
2015
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16. Clinical and Biologic Effects of the Angiopoietin 1/2 Neutralizing Peptibody Trebananib (AMG 386) in Acute Myeloid Leukemia Patients

Author

Wang Eunice S, Brady William, Wetzler Meir, Gaudy Allison, O'Dwyer Kristen, Greene Jessica, Tan Wei, Vigil Carlos E, Fetterly Gerald J, Becker Michael W, Mendler Jason H, and Liesveld Jane

Subjects
Cancer Research, medicine.medical_specialty, business.industry, Induction chemotherapy, Myeloid leukemia, Hematology, medicine.disease, Gastroenterology, Transplantation, medicine.anatomical_structure, Oncology, Tolerability, Pharmacokinetics, Internal medicine, Immunology, medicine, Cytarabine, Mucositis, Bone marrow, business, medicine.drug
Abstract

Background Marrow angiogenesis plays an important role in the pathogenesis of acute myeloid leukemia (AML). Among the most prominent pro-angiogenic factors produced by AML cells are the angiopoietins (Ang-1/2), ligands of the Tie2 endothelial cell receptor. Elevated expression of Ang-2 is an independent prognostic factor for overall survival in AML. Trebananib (AMG 386) is a first-in-class neutralizing peptibody that provides potent and selective inhibition of angiopoietins by sequestering Ang1 and Ang2 and preventing their interaction with the Tie2 receptor. Purpose Here we evaluated the safety, tolerability, pharmacokinetic profile, and biologic effects of trebananib in de novo and relapsed/refractory AML patients considered to be poor candidates for standard induction chemotherapy. Methods Thirteen AML patients were enrolled in single agent arm A of this open-label, non-randomized phase Ib trial. ([ClinicalTrials.gov][1] ID: [NCT01555268][2], NCI-2011-02979). Drug was administered at two dose levels (15 and 30 mg/kg) via weekly intravenous infusion over 1 hour. Circulating angiogenic factor levels (Ang-2, VEGF-A/C/D, HGF, IL-8, FGF-1/2, G-CSF, PlGF) in the plasma were measured by multiplex flow cytometry prior to first dose, on cycle 1 day 29 (following 4 weekly doses of trebananib), and at the end of study. Results Median age was 76 years (range 53-82). Nine patients were male (69%). Two patients had de novo, 7 had refractory, and 4 had relapsed AML. One patient had undergone prior allogeneic stem cell transplantation. Aside from one possibly drug-related incident of grade 3 mucositis on the 15 mg/kg cohort, no other dose-limiting toxicities were reported. The most common toxicities were abdominal bloating, diarrhea, edema, and weight gain. Preliminary pharmacokinetic analysis of trebananib was dose-proportional. At the 15 and 30 mg/kg dose levels, median Cmaxand AUC on Day 1 were 193 and 473 ug/mL and 11,670 and 35,217 ug-hr/mL, respectively. No neutralizing antibodies to trebananib were detected. Among seven AML patients with consecutive plasma samples, therapy was associated with marked elevations of Ang-2 levels (from 15 to 336-fold higher than baseline) after 1-4 weeks of therapy (Table 1). Induction of Ang-2 did not differ significantly between the 15 mg/kg and 30 mg/kg cohorts. Ang-2 levels measured in bone marrow or plasma samples at the same time point were comparable. In contrast, levels of other angiogenic growth factors (VEGF-A/C/D, IL-8, G-CSF, HGF, FGF-1/2, PlGF) were not consistently altered by trebananib therapy. One AML patient (on the 15 mg/kg cohort) had a partial response with >50% decrease in marrow blasts. Two patients (15 mg/kg, 30 mg/kg) had stable disease over >1 cycle. Conclusions We report here the preliminary results of phase 1b study evaluating the safety, tolerability, pharmacokinetic profile, and biologic effects of trebananib in adult AML patients. Weekly infusions of trebananib administered at 15 and 30 mg/kg were well tolerated. Drug pharmacokinetics were similar to those previously reported in solid tumor patients. Trebananib resulted in substantial elevations in measurable circulating and marrow Ang-2 levels in AML patients, presumably due to a negative compensatory feedback loop resulting from potent in vivo Ang-1/2 inhibition. Arm B of this study (trebananib plus low dose cytarabine) is currently accruing. Further in depth studies examining the biological effects of trebananib on marrow angiogenesis and clinical response in AML patients are ongoing. Disclosures: Becker: Millenium: Research Funding. [1]: http://ClinicalTrials.gov [2]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT01555268&atom=%2Fbloodjournal%2F122%2F21%2F2701.atom

Published
2014
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