1. Light and heavy chain deposition disease associated with CH1 deletion.
- Author
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Cohen, Camille, El-Karoui, Khalil, Alyanakian, Marie-Alexandra, Noel, Laure-Hélène, Bridoux, Franck, and Knebelmann, Bertrand
- Subjects
MONOCLONAL gammopathies ,MONOCLONAL antibodies ,RENAL biopsy ,GLOMERULOSCLEROSIS ,DIAGNOSTIC immunoblotting - Abstract
Light and heavy chain deposition disease (LHCDD) is a rare complication of monoclonal gammopathy. In all documented cases, LHCDD is the association of deposits of a monoclonal light chain with a normal heavy chain, especially in the kidneys. We describe here a 78-year-old woman whose renal biopsy showed nodular glomerulosclerosis, initially diagnosed as diabetic nephropathy. Detailed kidney biopsy immunofluorescence study corrected the diagnosis to γ1-ĸ-LHCDD. Advanced immunoblot analysis showed deletion of CH1 in the both blood and kidney heavy chain.We report here, to our knowledge, the first case of γ1 LHCDD associated with a deletion of CH1. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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