1. MicroRNAs in AKI and Kidney Transplantation.
- Author
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Ledeganck KJ, Gielis EM, Abramowicz D, Stenvinkel P, Shiels PG, and Van Craenenbroeck AH
- Subjects
- Acute Kidney Injury metabolism, Acute Kidney Injury physiopathology, Animals, Delayed Graft Function metabolism, Delayed Graft Function physiopathology, Gene Expression Regulation, Humans, MicroRNAs metabolism, Prognosis, Reperfusion Injury metabolism, Reperfusion Injury physiopathology, Risk Factors, Signal Transduction, Acute Kidney Injury genetics, Delayed Graft Function genetics, Kidney Transplantation adverse effects, MicroRNAs genetics, Reperfusion Injury genetics
- Abstract
MicroRNAs are epigenetic regulators of gene expression at the posttranscriptional level. They are involved in intercellular communication and crosstalk between different organs. As key regulators of homeostasis, their dysregulation underlies several morbidities including kidney disease. Moreover, their remarkable stability in plasma and urine makes them attractive biomarkers. Beyond biomarker studies, clinical microRNA research in nephrology in recent decades has focused on the discovery of specific microRNA signatures and the identification of novel targets for therapy and/or disease prevention. However, much of this research has produced equivocal results and there is a need for standardization and confirmation in prospective trials. This review aims to provide an overview of general concepts and available clinical evidence in both the pathophysiology and biomarker fields for the role of microRNA in AKI and kidney transplantation., (Copyright © 2019 by the American Society of Nephrology.)
- Published
- 2019
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