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Silvia Riva,1 Alessandro Nobili,2 Codjo D Djade,2 Maria Elisa Mancuso,3 Elena Santagostino,3 Gabriella Pravettoni1–4 1Department of Health Sciences, Università degli Studi di Milano, Milan, Italy; 2Department of Neuroscience, IRCCS, Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy; 3Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, IRCCS Ca’ Granda, Policlinic Hospital, Milan, Italy; 4European Institute of Oncology, Milan, Italy Abstract: Elderly patients with hemophilia have to face new challenges linked to concomitant pathologies and concurrent use of different treatments. In order to promote optimal care in the elderly hemophilia population, this study is aimed to analyze treatment compliance in relation to the presence of comorbidities and the role of potential determinants that can affect compliance (positively or negatively), including health-related quality of life, cognitive decline, and sociodemographic parameters (eg, living situation, partnership, presence of caregivers). This will be an observational study of elderly patients with hemophilia (aged >60 years). Patients will be interviewed during their routine medical visits. The data interview will pertaining to several dimension of treatment management. This study will detect more vulnerable patients with special care needs and will highlight psychological factors that should be considered for future psychosocial interventions.Keywords: hemophilia, cognitive assessment, cognitive decline, compliance, treatment, aging