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Start Over Author "Ecevit İZ" Journal clinical infectious diseases an official publication of the infectious diseases society of america

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1. The poor prognosis of central nervous system cryptococcosis among nonimmunosuppressed patients: a call for better disease recognition and evaluation of adjuncts to antifungal therapy.

Author

Ecevit IZ, Clancy CJ, Schmalfuss IM, and Nguyen MH

Subjects
Adult, Cerebral Infarction complications, Female, Humans, Immunosuppression Therapy, Male, Meningitis, Cryptococcal diagnosis, Middle Aged, Prognosis, Time Factors, Treatment Outcome, Antifungal Agents therapeutic use, Meningitis, Cryptococcal drug therapy, Meningitis, Cryptococcal immunology
Abstract

We describe 9 nonimmunosuppressed patients with central nervous system cryptococcosis. Morbidity and mortality were high, especially among patients with cerebral infarcts. This was attributed to delayed diagnosis and apparent sequelae of overwhelming host immune responses. We present clues suggesting the diagnosis. Increased recognition and timely diagnosis of this condition may improve outcomes.

Published
2006
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