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Start Over Author "Lugos, Moses D." Journal clinical infectious diseases
4 results on '"Lugos, Moses D."'

1. Quantitative T cell assay reflects infectious load of Mycobacterium tuberculosis in an endemic case contact model

Author

Hill, Philip C., Fox, Annette, Jeffries, David J., Jackson-Sillah, Dolly, Lugos, Moses D., Owiafe, Patrick K., Donkor, Simon A., Hammond, Abdulrahman S., Corrah, Tumani, Adegbola, Richard A., McAdam, Keith P.W.J., and Brookes, Roger H.

Subjects
T cells -- Research, Mycobacterium tuberculosis -- Risk factors, Mycobacterium tuberculosis -- Diagnosis, Mycobacterium tuberculosis -- Care and treatment, Medical research, Medicine, Experimental, Health, Health care industry
Published
2005

2. Large-scale evaluation of enzyme-linked immunospot assay and skin test for diagnosis of Mycobacterium tuberculosis infection against a gradient of exposure in the Gambia

Author

Hill, Philip C., Brookes, Roger H., Fox, Annette, Fielding, Katherine, Jeffries, David J., Jackson-Sillah, Dolly, Lugos, Moses D., Owiafe, Patrick K., Donkor, Simon A., Hammond, Abdulrahman S., Otu, Jacob K., Corrah, Tumani, Adegbola, Richard A., and McAdam, Keith P.W.J.

Subjects
Mycobacterium tuberculosis -- Diagnosis, Mycobacterium tuberculosis -- Research, Tuberculosis -- Diagnosis, Tuberculosis -- Research, Health, Health care industry
Published
2004

3. Large‐Scale Evaluation of Enzyme‐Linked Immunospot Assay and Skin Test for Diagnosis ofMycobacterium tuberculosisInfection against a Gradient of Exposure in The Gambia

Author

Hill, Philip C., primary, Brookes, Roger H., additional, Fox, Annette, additional, Fielding, Katherine, additional, Jeffries, David J., additional, Jackson‐Sillah, Dolly, additional, Lugos, Moses D., additional, Owiafe, Patrick K., additional, Donkor, Simon A., additional, Hammond, Abdulrahman S., additional, Otu, Jacob K., additional, Corrah, Tumani, additional, Adegbola, Richard A., additional, and McAdam, Keith P. W. J., additional

Published
2004
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4. Large-Scale Evaluation of Enzyme-Linked Immunospot Assay and Skin Test for Diagnosis of Mycobacterium tuberculosis Infection against a Gradient of Exposure in The Gambia.

Author

Brookes, Roger H., Fox, Annette, Fielding, Katherine, Jeffries, David J., Jackson-Sillah, Dolly, Lugos, Moses D., Owiafe, Patrick K., Donkor, Simon A., Hammond, Abdulrahman S., Otu, Jacob K., Corrah, Tumani, Adegbola, Richard A., McAdam, Keith P. W. J., and Hill, Philip C.

Subjects
MYCOBACTERIUM tuberculosis, SKIN tests, ENZYME-linked immunosorbent assay, BCG vaccines, DIAGNOSIS
Abstract

The purified protein derivative (PPD) skin test for Mycobacterium tuberculosis infection lacks specificity. We assessed 2 more specific M. tuberculosis antigens (ESAT-6 and CFP-10) by enzyme-linked immunospot assay (ELISPOT) compared with PPD by ELISPOT and skin test in The Gambia. Of 735 household contacts of 130 sputum smear–positive tuberculosis cases, 476 (65%) tested positive by PPD ELISPOT, 300 (41%) tested positive by PPD skin test, and 218 (30%) tested positive by ESAT-6/CFP-10 ELISPOT. Only 15 (2%) had positive ESAT- 6/CFP-10 results and negative PPD results by ELISPOT. With increasing M. tuberculosis exposure, the percentage of subjects who were PPD skin test positive/ESAT-6/CFP-10 ELISPOT negative increased (P < .001) whereas the percentage of subjects who were PPD skin test negative/PPD ELISPOT positive decreased (Pp ). Eighteen (31%) SAT-6/CFP-10 ELISPOT–positive subjects in the lowest exposure category had negative .011 PPD skin test results. ESAT-6/CFP-10 ELISPOT probably offers increased specificity in the diagnosis of M. tuberculosis infection in this tropical setting of endemicity, at the cost of some sensitivity. [ABSTRACT FROM AUTHOR]

Published
2004

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