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Your search keyword '"Humphrey, Jean"' showing total 15 results
Start Over Author "Humphrey, Jean" Journal clinical infectious diseases
15 results on '"Humphrey, Jean"'

1. Contribution of Maternal Antiretroviral Therapy and Breastfeeding to 24-Month Survival in Human Immunodeficiency Virus-Exposed Uninfected Children : An Individual Pooled Analysis of African and Asian Studies

Author

Arikawa, Shino, Rollins, Nigel, Jourdain, Gonzague, Humphrey, Jean, Kourtis, Athena P., Hoffman, Irving, Essex, Max, Farley, Tim, Coovadia, Hoosen M., Gray, Glenda, Kuhn, Louise, Shapiro, Roger, Leroy, Valériane, Bollinger, Robert C., Onyango-Makumbi, Carolyne, Lockman, Shahin, Marquez, Carina, Doherty, Tanya, Dabis, François, Mandelbrot, Laurent, Le Coeur, Sophie, Rolland, Matthieu, Joly, Pierre, Newell, Marie-Louise, and Becquet, Renaud

Published
2018

8. The Impact of Improved Water, Sanitation, and Hygiene on Oral Rotavirus Vaccine Immunogenicity in Zimbabwean Infants: Substudy of a Cluster-randomized Trial

Author

Church, James A, primary, Rukobo, Sandra, additional, Govha, Margaret, additional, Lee, Benjamin, additional, Carmolli, Marya P, additional, Chasekwa, Bernard, additional, Ntozini, Robert, additional, Mutasa, Kuda, additional, McNeal, Monica M, additional, Majo, Florence D, additional, Tavengwa, Naume V, additional, Moulton, Lawrence H, additional, Humphrey, Jean H, additional, Kirkpatrick, Beth D, additional, and Prendergast, Andrew J, additional

Published
2019
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9. Mortality, Human Immunodeficiency Virus (HIV) Transmission, and Growth in Children Exposed to HIV in Rural Zimbabwe.

Author

Evans, Ceri, Chasekwa, Bernard, Ntozini, Robert, Majo, Florence D, Mutasa, Kuda, Tavengwa, Naume, Mutasa, Batsirai, Mbuya, Mduduzi N N, Smith, Laura E, Stoltzfus, Rebecca J, Moulton, Lawrence H, Humphrey, Jean H, Prendergast, Andrew J, and Team, for the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial

Subjects
HIV prevention, HIV infection transmission, ANTHROPOMETRY, COMPARATIVE studies, CONFIDENCE intervals, GROWTH disorders, HIV, HIV infections, HIV-positive persons, HUMAN growth, INFANT mortality, MEDICAL screening, MOTHERS, RURAL conditions, ANTIRETROVIRAL agents, VERTICAL transmission (Communicable diseases), DESCRIPTIVE statistics, CHILDREN, FETUS
Abstract

Background Clinical outcomes of children who are human immunodeficiency virus (HIV)–exposed in sub-Saharan Africa remain uncertain. Methods The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial evaluated improved infant and young child feeding (IYCF) and/or improved water, sanitation, and hygiene in 2 rural Zimbabwean districts with 15% antenatal HIV prevalence and > 80% prevention of mother-to-child transmission (PMTCT) coverage. Children born between February 2013 and December 2015 had longitudinal HIV testing and anthropometry. We compared mortality and growth between children who were HIV-exposed and HIV-unexposed through 18 months. Children receiving IYCF were excluded from growth analyses. Results Fifty-one of 738 (7%) children who were HIV-exposed and 198 of 3989 (5%) children who were HIV-unexposed (CHU) died (hazard ratio, 1.41 [95% confidence interval {CI}, 1.02–1.93]). Twenty-five (3%) children who were HIV-exposed tested HIV positive, 596 (81%) were HIV-exposed uninfected (CHEU), and 117 (16%) had unknown HIV status by 18 months; overall transmission estimates were 4.3%–7.7%. Mean length-for-age z score at 18 months was 0.38 (95% CI,.24–.51) standard deviations lower among CHEU compared to CHU. Among 367 children exposed to HIV in non-IYCF arms, 147 (40%) were alive, HIV-free, and nonstunted at 18 months, compared to 1169 of 1956 (60%) CHU (absolute difference, 20% [95% CI, 15%–26%]). Conclusions In rural Zimbabwe, mortality remains 40% higher among children exposed to HIV, vertical transmission exceeds elimination targets, and half of CHEU are stunted. We propose the composite outcome of "alive, HIV free, and thriving" as the long-term goal of PMTCT programs. Clinical Trials Registration NCT01824940. [ABSTRACT FROM AUTHOR]

Published
2021
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10. Contribution of Maternal Antiretroviral Therapy and Breastfeeding to 24-Month Survival in Human Immunodeficiency Virus-Exposed Uninfected Children: An Individual Pooled Analysis of African and Asian Studies

Author

Arikawa, Shino, primary, Rollins, Nigel, additional, Jourdain, Gonzague, additional, Humphrey, Jean, additional, Kourtis, Athena P, additional, Hoffman, Irving, additional, Essex, Max, additional, Farley, Tim, additional, Coovadia, Hoosen M, additional, Gray, Glenda, additional, Kuhn, Louise, additional, Shapiro, Roger, additional, Leroy, Valériane, additional, Bollinger, Robert C, additional, Onyango-Makumbi, Carolyne, additional, Lockman, Shahin, additional, Marquez, Carina, additional, Doherty, Tanya, additional, Dabis, François, additional, Mandelbrot, Laurent, additional, Le Coeur, Sophie, additional, Rolland, Matthieu, additional, Joly, Pierre, additional, Newell, Marie-Louise, additional, and Becquet, Renaud, additional

Published
2017
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12. Design of an Intervention to Minimize Ingestion of Fecal Microbes by Young Children in Rural Zimbabwe: Table 1.

Author

Mbuya, Mduduzi N. N., primary, Tavengwa, Naume V., additional, Stoltzfus, Rebecca J., additional, Curtis, Valerie, additional, Pelto, Gretel H., additional, Ntozini, Robert, additional, Kambarami, Rukundo A., additional, Fundira, Dadirai, additional, Malaba, Thokozile R., additional, Maunze, Diana, additional, Morgan, Peter, additional, Mangwadu, Goldberg, additional, and Humphrey, Jean H., additional

Published
2015
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15. Using Geographic Information Systems and Spatial Analysis Methods to Assess Household Water Access and Sanitation Coverage in the SHINE Trial

Author

Ntozini, Robert, primary, Marks, Sara J., additional, Mangwadu, Goldberg, additional, Mbuya, Mduduzi N. N., additional, Gerema, Grace, additional, Mutasa, Batsirai, additional, Julian, Timothy R., additional, Schwab, Kellogg J., additional, Humphrey, Jean H., additional, and Zungu, Lindiwe I., additional

Published
2015
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