1. Delayed mortality among solid organ transplant recipients hospitalized for COVID-19
- Author
-
Madeleine R, Heldman, Olivia S, Kates, Kassem, Safa, Camille N, Kotton, Ashrit, Multani, Sarah J, Georgia, Julie M, Steinbrink, Barbara D, Alexander, Emily A, Blumberg, Brandy, Haydel, Vagish, Hemmige, Marion, Hemmersbach-Miller, Ricardo M, La Hoz, Lisset, Moni, Yesabeli, Condor, Sandra, Flores, Carlos G, Munoz, Juan, Guitierrez, Esther I, Diaz, Daniela, Diaz, Rodrigo, Vianna, Giselle, Guerra, Matthias, Loebe, Julie M, Yabu, Kailey Hughes, Kramer, Sajal D, Tanna, Michael G, Ison, Robert M, Rakita, Maricar, Malinis, Marwan M, Azar, Margaret E, McCort, Pooja P, Singh, Arzu, Velioglu, Sapna A, Mehta, David, van Duin, Jason D, Goldman, Erika D, Lease, Anna, Wald, Ajit P, Limaye, Cynthia E, Fisher, and Heldman M. R., Kates O. S., Safa K., Kotton C. N., Multani A., Georgia S. J., Steinbrink J. M., Alexander B. D., Blumberg E. A., Haydel B., et al.
- Subjects
Microbiology (medical) ,Infectious Diseases - Abstract
Introduction Most studies of solid organ transplant (SOT) recipients with COVID-19 focus on outcomes within one month of illness onset. Delayed mortality in SOT recipients hospitalized for COVID-19 has not been fully examined. Methods We used data from a multicenter registry to calculate mortality by 90 days following initial SARS-CoV-2 detection in SOT recipients hospitalized for COVID-19 and developed multivariable Cox proportional-hazards models to compare risk factors for death by days 28 and 90. Results Vital status at day 90 was available for 936 of 1117 (84%) SOT recipients hospitalized for COVID-19: 190 of 936 (20%) died by 28 days and an additional 56 of 246 deaths (23%) occurred between days 29 and 90. Factors associated with mortality by day 90 included: age > 65 years [aHR 1.8 (1.3-2.4), p = Conclusions In SOT recipients hospitalized for COVID-19, >20% of deaths occurred between 28 and 90 days following SARS-CoV-2 diagnosis. Future investigations should consider extending follow-up duration to 90 days for more complete mortality assessment
- Published
- 2022
- Full Text
- View/download PDF