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Your search keyword '"Adegbola, Richard A"' showing total 26 results
Start Over Author "Adegbola, Richard A" Journal clinical infectious diseases
26 results on '"Adegbola, Richard A"'

4. Ethical Challenges and Lessons Learned During the Clinical Development of a Group A Meningococcal Conjugate Vaccine

Author

Martellet, Lionel, Sow, Samba O., Diallo, Aldiouma, Hodgson, Abraham, Kampmann, Beate, Hirve, Siddhivinayak, Tapia, Milagritos, Haidara, Fadima Cheick, Ndiaye, Assane, Diarra, Bou, Ansah, Patrick Odum, Akinsola, Adebayo, Idoko, Olubukola T., Adegbola, Richard A., Bavdekar, Ashish, Juvekar, Sanjay, Viviani, Simonetta, Enwere, Godwin C., Marchetti, Elisa, Chaumont, Julie, Makadi, Marie-Francoise, Pallardy, Flore, Kulkarni, Prasad S., Preziosi, Marie-Pierre, and LaForce, F. Marc

Published
2015

5. Antibody Persistence 1–5 Years Following Vaccination With MenAfriVac in African Children Vaccinated at 12–23 Months of Age

Author

Tapia, Milagritos D., Findlow, Helen, Idoko, Olubukola T., Preziosi, Marie-Pierre, Kulkarni, Prasad S., Enwere, Godwin C., Elie, Cheryl, Parulekar, Varsha, Sow, Samba O., Haidara, Fadima Cheick, Diallo, Fatoumata, Doumbia, Moussa, Akinsola, Adebayo K., Adegbola, Richard A., Kampmann, Beate, Chaumont, Julie, Martellet, Lionel, Marchetti, Elisa, Viviani, Simonetta, Tang, Yuxiao, Plikaytis, Brian D., LaForce, F. Marc, Carlone, George, and Borrow, Ray

Published
2015

6. Antibody Persistence at 1 and 4 Years Following a Single Dose of MenAfriVac or Quadrivalent Polysaccharide Vaccine in Healthy Subjects Aged 2–29 Years

Author

Diallo, Aldiouma, Sow, Samba O., Idoko, Olubukola T., Hirve, Siddhivinayak, Findlow, Helen, Preziosi, Marie-Pierre, Elie, Cheryl, Kulkarni, Prasad S., Parulekar, Varsha, Diarra, Bou, Haidara, Fadima Cheick, Diallo, Fatoumata, Tapia, Milagritos, Akinsola, Adebayo K., Adegbola, Richard A., Bavdekar, Ashish, Juvekar, Sanjay, Chaumont, Julie, Martellet, Lionel, Marchetti, Elisa, LaForce, Marc F., Plikaytis, Brian D., Enwere, Godwin C., Tang, Yuxiao, Borrow, Ray, Carlone, George, and Viviani, Simonetta

Published
2015

7. Shigella Isolates From the Global Enteric Multicenter Study Inform Vaccine Development

Author

Livio, Sofie, Strockbine, Nancy A., Panchalingam, Sandra, Tennant, Sharon M., Barry, Eileen M., Marohn, Mark E., Antonio, Martin, Hossain, Anowar, Mandomando, Inacio, Ochieng, John B., Oundo, Joseph O., Qureshi, Shahida, Ramamurthy, Thandavarayan, Tamboura, Boubou, Adegbola, Richard A., Hossain, Mohammed Jahangir, Saha, Debasish, Sen, Sunil, Faruque, Abu Syed Golam, Alonso, Pedro L., Breiman, Robert F., Zaidi, Anita K. M., Sur, Dipika, Sow, Samba O., Berkeley, Lynette Y., O'Reilly, Ciara E., Mintz, Eric D., Biswas, Kousick, Cohen, Dani, Farag, Tamer H., Nasrin, Dilruba, Wu, Yukun, Blackwelder, William C., Kotloff, Karen L., Nataro, James P., and Levine, Myron M.

Published
2014
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8. Etiology of Severe Childhood Pneumonia in The Gambia, West Africa, Determined by Conventional and Molecular Microbiological Analyses of Lung and Pleural Aspirate Samples

Author

Howie, Stephen R. C., Morris, Gerard A. J., Tokarz, Rafal, Ebruke, Bernard E., Machuka, Eunice M., Ideh, Readon C., Chimah, Osaretin, Secka, Ousman, Townend, John, Dione, Michel, Oluwalana, Claire, Njie, Malick, Jallow, Mariatou, Hill, Philip C., Antonio, Martin, Greenwood, Brian, Briese, Thomas, Mulholland, Kim, Corrah, Tumani, Lipkin, W. Ian, and Adegbola, Richard A.

Published
2014
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11. The Global Enteric Multicenter Study (GEMS) of Diarrheal Disease in Infants and Young Children in Developing Countries: Epidemiologic and Clinical Methods of the Case/Control Study

Author

Kotloff, Karen L., Blackwelder, William C., Nasrin, Dilruba, Nataro, James P., Farag, Tamer H., van Eijk, Annemieke, Adegbola, Richard A., Alonso, Pedro L., Breiman, Robert F., Faruque, Abu Syed Golam, Saha, Debasish, Sow, Samba O., Sur, Dipika, Zaidi, Anita K. M., Biswas, Kousick, Panchalingam, Sandra, Clemens, John D., Cohen, Dani, Glass, Roger I., Mintz, Eric D., Sommerfelt, Halvor, and Levine, Myron M.

Published
2012
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17. Nasopharyngeal carriage of streptococcus pneumoniae in Gambian villagers

Author

Hill, Philip C., Akisanya, Abiodun, Sankareh, Kawsu, Cheung, Yin Bun, Saaka, Mark, Lahai, George, Greenwood, Brian M., and Adegbola, Richard A.

Subjects
Streptococcus pneumoniae -- Research, Streptococcus pneumoniae -- Care and treatment, Streptococcus pneumoniae -- Demographic aspects, Bacterial vaccines -- Usage, Bacterial vaccines -- Research, Nasopharynx -- Diseases, Nasopharynx -- Physiological aspects, Health, Health care industry
Published
2006

18. Quantitative T cell assay reflects infectious load of Mycobacterium tuberculosis in an endemic case contact model

Author

Hill, Philip C., Fox, Annette, Jeffries, David J., Jackson-Sillah, Dolly, Lugos, Moses D., Owiafe, Patrick K., Donkor, Simon A., Hammond, Abdulrahman S., Corrah, Tumani, Adegbola, Richard A., McAdam, Keith P.W.J., and Brookes, Roger H.

Subjects
T cells -- Research, Mycobacterium tuberculosis -- Risk factors, Mycobacterium tuberculosis -- Diagnosis, Mycobacterium tuberculosis -- Care and treatment, Medical research, Medicine, Experimental, Health, Health care industry
Published
2005

19. Large-scale evaluation of enzyme-linked immunospot assay and skin test for diagnosis of Mycobacterium tuberculosis infection against a gradient of exposure in the Gambia

Author

Hill, Philip C., Brookes, Roger H., Fox, Annette, Fielding, Katherine, Jeffries, David J., Jackson-Sillah, Dolly, Lugos, Moses D., Owiafe, Patrick K., Donkor, Simon A., Hammond, Abdulrahman S., Otu, Jacob K., Corrah, Tumani, Adegbola, Richard A., and McAdam, Keith P.W.J.

Subjects
Mycobacterium tuberculosis -- Diagnosis, Mycobacterium tuberculosis -- Research, Tuberculosis -- Diagnosis, Tuberculosis -- Research, Health, Health care industry
Published
2004

20. Persistent and Emerging Pneumococcal Carriage Serotypes in a Rural Gambian Community After 10 Years of Pneumococcal Conjugate Vaccine Pressure

Author

Usuf, Effua, primary, Bottomley, Christian, additional, Gladstone, Rebecca, additional, Bojang, Ebrima, additional, Jawneh, Kaddijatou, additional, Cox, Isatou, additional, Jallow, Edrissa, additional, Bojang, Abdoulie, additional, Greenwood, Brian, additional, Adegbola, Richard A, additional, Bentley, Stephen D, additional, Hill, Philip C, additional, and Roca, Anna, additional

Published
2020
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21. Persistent and Emerging Pneumococcal Carriage Serotypes in a Rural Gambian Community After 10 Years of Pneumococcal Conjugate Vaccine Pressure.

Author

Usuf, Effua, Bottomley, Christian, Gladstone, Rebecca, Bojang, Ebrima, Jawneh, Kaddijatou, Cox, Isatou, Jallow, Edrissa, Bojang, Abdoulie, Greenwood, Brian, Adegbola, Richard A, Bentley, Stephen D, Hill, Philip C, and Roca, Anna

Subjects
CROSS-sectional method, AGE distribution, STREPTOCOCCAL diseases, PNEUMOCOCCAL vaccines, SEROTYPES, STREPTOCOCCUS, GAMBIANS, GENOMICS, DESCRIPTIVE statistics, CARRIER state (Communicable diseases)
Abstract

Background The continuing impact of pneumococcal conjugate vaccines (PCVs) in regions with high pneumococcal transmission is threatened by the persistence of vaccine serotypes (VTs) and the emergence of nonvaccine serotypes (NVTs). Methods In 2016, we conducted a cross-sectional carriage survey (CSS5) in a community where PCV7 was first introduced in 2006 during a cluster-randomized trial conducted before nationwide introduction of PCV7 (2009) and PCV13 (2011). We estimated prevalence of PCV13 VT and NVT by age and compared these with earlier surveys before (CSS0), during (CSS1-3), and after the trial but before PCV13 (CSS4). Genomic analysis was conducted for the nontypeable pneumococci. Results Prevalence of PCV13 VT carriage decreased during the 10 years between CSS0 and CSS5 across all age groups (67.6% to 13.5%, P <.001; 59.8% to 14.4%, P <.001; 43.1% to 17.9%, P <.001; and 24.0% to 5.1%, P <.001, in <2, 2–4, 5–14, and ≥15 years, respectively). However, there was no difference between CSS4 and CSS5 in children ≥2 years and adults (children <2 years, no data). The prevalence of PCV13 NVT increased between CSS0 and CSS5 for children <2 years but decreased in older children and adults. In CSS5, serotypes 3, 6A, and 19F were the most common VT and nontypeable isolates were the most common NVT. Among nontypeable isolates, 73.0% lost the ability to express a capsule. Of these, 70.8% were from a VT background. Conclusions The decrease in PCV13 VT that has occurred since the introduction of PCV13 appears to have plateaued. Significant carriage of these serotypes remains in all age groups. [ABSTRACT FROM AUTHOR]

Published
2021
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23. Large‐Scale Evaluation of Enzyme‐Linked Immunospot Assay and Skin Test for Diagnosis ofMycobacterium tuberculosisInfection against a Gradient of Exposure in The Gambia

Author

Hill, Philip C., primary, Brookes, Roger H., additional, Fox, Annette, additional, Fielding, Katherine, additional, Jeffries, David J., additional, Jackson‐Sillah, Dolly, additional, Lugos, Moses D., additional, Owiafe, Patrick K., additional, Donkor, Simon A., additional, Hammond, Abdulrahman S., additional, Otu, Jacob K., additional, Corrah, Tumani, additional, Adegbola, Richard A., additional, and McAdam, Keith P. W. J., additional

Published
2004
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24. Childhood Pneumonia as a Global Health Priority and the Strategic Interest, Bill & Melinda Gates Foundation.

Author

Adegbola, Richard A.

Subjects
PNEUMONIA in children, PNEUMONIA-related mortality, PNEUMONIA vaccines, HIV, ETIOLOGY of diseases, STREPTOCOCCUS pneumoniae
Abstract

Pneumonia kills more children than any other disease-more than HIV/AIDS, malaria, and measles combined. Introduction of vaccines against pneumococcus and Haemophilus influenzae type b (themost important causes of severe pneumonia in young children), increasing resistance to antibiotics, and changes in HIV prevalence will likely change patterns of pneumonia etiology in developing countries. Studies such as Pneumonia Etiology Research for Child Health (PERCH) that take advantage of new diagnostic technologies are needed to provide an updated and more precise description of the microbial causes of pneumonia and to inform decisions around treatment algorithms and vaccine development and introduction. In recognition of its importance for global health and especially its significance as an ongoing cause of gross inequity in risks, The Bill & Melinda Gates Foundation has made pneumonia an important part of its global health strategy and PERCH a centerpiece of its Pneumonia Program. [ABSTRACT FROM AUTHOR]

Published
2012
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25. Transmission of Streptococcus pneumoniaein Rural Gambian Villages: A Longitudinal Study.

Author

Hill, Philip C., Townend, John, Antonio, Martin, Akisanya, Biodun, Ebruke, Chinelo, Lahai, George, Greenwood, Brian M., and Adegbola, Richard A.

Subjects
STREPTOCOCCUS pneumoniae, PREVENTIVE medicine, PNEUMOCOCCAL vaccines, VALENCE (Chemistry), IMMUNIZATION, SEROTYPES, VACCINATION, PNEUMONIA
Abstract

Background. To prepare for national introduction of a pneumococcal vaccine of restricted valency, we studied the pattern of nasopharyngeal carriage of Streptococcus pneumoniae and its transmission in Gambian villages over time. Methods. We collected nasopharyngeal swab specimens every 2 weeks from 158 villagers in 19 households in 2 villages over 1 year. We studied the prevalence and duration of S. pneumoniae carriage, the effect of household size and composition on carriage, and sequence type-specific carriage within and between households. Results. Ninety-seven percent of children and 85% of adults carried S. pneumoniae at some time. Fifty-three serotypes were represented among 1522 isolates. Carriage was more common among children than adults for all serotypes studied except 9V. There was an overall trend toward shorter carriage with increasing age (Pp.043) and significant differences in carriage duration between serotypes. For most serotypes, the odds of being a carrier were greater if there were other carriers in the household. The prevalence of carriage varied by serotype. Most notably, serotype 5 carriage occurred in only 1 village and was transient. Multilocus sequence typing of serotype 6B isolates from 1 village revealed 8 different sequence types and strong evidence of nonrandom distribution among households (P!.001). Study by sequence type suggested household spread starting most commonly in children, followed by spread to adults. Conclusions. This longitudinal carriage study in Gambian villages provides unique information on the pattern of spread of S. pneumoniae in rural Africa and a baseline for evaluating the impact of the introduction of pneumococcal conjugate vaccine into the region. [ABSTRACT FROM AUTHOR]

Published
2010
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26. Large-Scale Evaluation of Enzyme-Linked Immunospot Assay and Skin Test for Diagnosis of Mycobacterium tuberculosis Infection against a Gradient of Exposure in The Gambia.

Author

Brookes, Roger H., Fox, Annette, Fielding, Katherine, Jeffries, David J., Jackson-Sillah, Dolly, Lugos, Moses D., Owiafe, Patrick K., Donkor, Simon A., Hammond, Abdulrahman S., Otu, Jacob K., Corrah, Tumani, Adegbola, Richard A., McAdam, Keith P. W. J., and Hill, Philip C.

Subjects
MYCOBACTERIUM tuberculosis, SKIN tests, ENZYME-linked immunosorbent assay, BCG vaccines, DIAGNOSIS
Abstract

The purified protein derivative (PPD) skin test for Mycobacterium tuberculosis infection lacks specificity. We assessed 2 more specific M. tuberculosis antigens (ESAT-6 and CFP-10) by enzyme-linked immunospot assay (ELISPOT) compared with PPD by ELISPOT and skin test in The Gambia. Of 735 household contacts of 130 sputum smear–positive tuberculosis cases, 476 (65%) tested positive by PPD ELISPOT, 300 (41%) tested positive by PPD skin test, and 218 (30%) tested positive by ESAT-6/CFP-10 ELISPOT. Only 15 (2%) had positive ESAT- 6/CFP-10 results and negative PPD results by ELISPOT. With increasing M. tuberculosis exposure, the percentage of subjects who were PPD skin test positive/ESAT-6/CFP-10 ELISPOT negative increased (P < .001) whereas the percentage of subjects who were PPD skin test negative/PPD ELISPOT positive decreased (Pp ). Eighteen (31%) SAT-6/CFP-10 ELISPOT–positive subjects in the lowest exposure category had negative .011 PPD skin test results. ESAT-6/CFP-10 ELISPOT probably offers increased specificity in the diagnosis of M. tuberculosis infection in this tropical setting of endemicity, at the cost of some sensitivity. [ABSTRACT FROM AUTHOR]

Published
2004

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