1. Prognostic role of circulating neutrophil extracellular traps levels for long-term mortality in new end-stage renal disease patients
- Author
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Hoi Woul Lee, Jwa-Kyung Kim, Sung Gyun Kim, Young Rim Song, Narae Joo, Hyung Jik Kim, and Hyung Seok Lee
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Neutrophils ,medicine.medical_treatment ,Immunology ,Extracellular Traps ,Gastroenterology ,End stage renal disease ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Renal Dialysis ,In vivo ,Internal medicine ,Deoxyribonuclease I ,Humans ,Immunology and Allergy ,Medicine ,Aged ,Peroxidase ,Aged, 80 and over ,Innate immune system ,biology ,business.industry ,Neutrophil extracellular traps ,Middle Aged ,Atherosclerosis ,Prognosis ,medicine.disease ,Survival Analysis ,Uremia ,Nucleosomes ,030104 developmental biology ,Myeloperoxidase ,biology.protein ,Kidney Failure, Chronic ,Biomarker (medicine) ,Female ,Hemodialysis ,business ,Biomarkers ,030215 immunology - Abstract
Dysregulation of innate immunity has been proposed as an important contributing factor for advanced atherosclerosis and resultant high mortality in hemodialysis (HD) patients. To evaluate the long-term prognostic role of in vivo neutrophil extracellular traps (NETs), we measured circulating serum nucleosome, myeloperoxidase (MPO), and DNase I levels in 281 incident HD patients. Circulating nucleosome level was significantly higher in HD patients compared to controls, and it was closely associated with MPO levels, suggesting increased in vivo NETs in uremia. Patients in the nucleosome Q4 group had significantly increased all-cause and adverse CV mortality compared to those in the Q1–3 group even after adjusting traditional risk factors Also, serum DNase I level was significantly higher in HD patients than controls (2.76 ± 1.02 ng/ml and 1.93 ± 0.85 ng/ml), but it had no correlation with NETs. Interestingly, it serves an additive biomarker for predicting poor CV outcomes. The two novel biomarkers might provide an importance independent prognostic significance in incident HD patients.
- Published
- 2020
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