1. Contrast-enhanced ultrasonography in differential diagnosis of focal gallbladder adenomyomatosis and gallbladder cancer
- Author
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Le-Wu Lin, Jie-Xian Wen, Wen-Ping Wang, Qing Yu, Hai-Xia Yuan, Pei-Shan Guan, and Xue-Jun Chen
- Subjects
Male ,Physiology ,030218 nuclear medicine & medical imaging ,Lesion ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,Medicine ,Humans ,Gallbladder cancer ,Adenomyomatosis ,Ultrasonography ,business.industry ,Gallbladder ,Ultrasound ,Hematology ,Blood flow ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,030211 gastroenterology & hepatology ,Female ,Gallbladder Neoplasms ,Differential diagnosis ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,Adenomyoma ,Contrast-enhanced ultrasound - Abstract
BACKGROUND Focal gallbladder adenomyomatosis (ADM) is a common disease that mimics gallbladder cancer (GBC) on ultrasonography. OBJECTIVE Here we aim to assess the value of contrast-enhanced ultrasound (CEUS) in differentiating ADM from GBC. METHODS Forty-one histopathologically proven focal ADMs and 34 GBCs (≤T2 stage) were enrolled in the study. Lesion location, blood flow signals, contrast pattern and appearance on contrast-enhanced ultrasound (CEUS) were compared respectively. RESULTS Lesions were detected in fundus, body, neck at the rates of 61.0% (25/41), 26.8% (11/41) and 12.2% (5/41), respectively, in ADM patients, in comparison to 29.4% (10/34), 32.4% (11/34) and 38.2% (13/34), respectively, in GBC patients (p = 0.009). Blood flow signals were detected in 19.5% (8/41) of cases in ADMs, compared to 58.8% (20/34) in GBCs (p = 0.001). On CEUS, iso-enhancement, hypo-enhancement, intramural anechoic space and intactness of GB wall were detected in 41.5% (17/41), 39.0% (16/41), 56.1% (23/41) and 80.5% (33/41) cases of ADMs, in contrast to 17.6% (6/34), 20.6% (7/34), 20.6% (7/34) and 17.6% (6/34) of GBCs (p = 0.001, p = 0.001, p = 0.002, p
- Published
- 2018