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Your search keyword '"Matteo Giovanni Carrabba"' showing total 2 results
Start Over Author "Matteo Giovanni Carrabba" Journal clinical hematology international
2 results on '"Matteo Giovanni Carrabba"'

1. Nanosphere's Verigene® Blood Culture Assay to Detect Multidrug-Resistant Gram-Negative Bacterial Outbreak: A Prospective Study on 79 Hematological Patients in a Country with High Prevalence of Antimicrobial Resistance

Author

Raffaella Greco, Maria Chiara Barbanti, Nicasio Mancini, Laura Infurnari, Renée Pasciuta, Alessandra Forcina, Chiara Oltolini, Gabriele Casirati, Daniele Mannina, Fabio Giglio, Carlo Messina, Mara Morelli, Francesca Lorentino, Sara Mastaglio, Tommaso Perini, Luca Vago, Paolo Scarpellini, Matteo Giovanni Carrabba, Maria Teresa Lupo Stanghellini, Sarah Marktel, Andrea Assanelli, Massimo Bernardi, Consuelo Corti, Jacopo Peccatori, Massimo Clementi, and Fabio Ciceri

Subjects
Sepsis, Hematological patients, Molecular diagnosis, Carbapenem resistance, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Infections are a major cause of morbidity and mortality in hematological patients. We prospectively tested a new molecular assay (Verigene®) in 79 consecutive hematological patients, with sepsis by gram-negative bacteria. A total of 82 gram-negative microorganisms were isolated by blood cultures, of which 76 cases were mono-microbial. Considering the bacteria detectable by the system, the concordance with standard blood cultures was 100%. Resistance genes were detected in 20 of the isolates and 100% were concordant with the phenotypic antibiotic resistance. Overall, this new assay correctly identified 66/82 of all the gram-negative pathogens, yielding a general sensitivity of 80.5%, and providing information on genetic antibiotic resistance in a few hours. This new molecular assay could ameliorate patient management, resulting in a more rational use of antibiotics.

Published
2019
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2. Nanosphere's Verigene

Author

Raffaella, Greco, Maria Chiara, Barbanti, Nicasio, Mancini, Laura, Infurnari, Renée, Pasciuta, Alessandra, Forcina, Chiara, Oltolini, Gabriele, Casirati, Daniele, Mannina, Fabio, Giglio, Carlo, Messina, Mara, Morelli, Francesca, Lorentino, Sara, Mastaglio, Tommaso, Perini, Luca, Vago, Paolo, Scarpellini, Matteo Giovanni, Carrabba, Maria Teresa Lupo, Stanghellini, Sarah, Marktel, Andrea, Assanelli, Massimo, Bernardi, Consuelo, Corti, Jacopo, Peccatori, Massimo, Clementi, and Fabio, Ciceri

Subjects
Hematological patients, Carbapenem resistance, Sepsis, Molecular diagnosis, Research Article
Abstract

Infections are a major cause of morbidity and mortality in hematological patients. We prospectively tested a new molecular assay (Verigene®) in 79 consecutive hematological patients, with sepsis by gram-negative bacteria. A total of 82 gram-negative microorganisms were isolated by blood cultures, of which 76 cases were mono-microbial. Considering the bacteria detectable by the system, the concordance with standard blood cultures was 100%. Resistance genes were detected in 20 of the isolates and 100% were concordant with the phenotypic antibiotic resistance. Overall, this new assay correctly identified 66/82 of all the gram-negative pathogens, yielding a general sensitivity of 80.5%, and providing information on genetic antibiotic resistance in a few hours. This new molecular assay could ameliorate patient management, resulting in a more rational use of antibiotics.

Published
2019

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