1. Urticaria, arthralgia, and nephropathy without amyloidosis: another variant of the Muckle-Wells syndrome?
- Author
-
D. Throssell, John Walls, Richard C. Trembath, and John Feehally
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Urticaria ,Sensorineural deafness ,Deafness ,Inherited Predisposition ,Nephropathy ,Muckle–Wells syndrome ,Pregnancy ,Immunopathology ,otorhinolaryngologic diseases ,Genetics ,medicine ,Humans ,skin and connective tissue diseases ,Genetics (clinical) ,business.industry ,Amyloidosis ,Syndrome ,Middle Aged ,medicine.disease ,Dermatology ,Arthralgia ,Female ,Kidney Diseases ,Skeletal abnormalities ,business - Abstract
The term Muckle-Wells syndrome (MWS) describes an autosomal dominant disorder characterised by various combinations of urticaria, sensorineural deafness, amyloidosis, arthralgia and skeletal abnormalities. We describe a family with nephropathy and several symptoms of MWS, but no evidence of deafness or amyloidosis. Since nephropathy without amyloidosis has never been reported in MWS, but deafness is a feature of all reported pedigrees, we conclude that members of this family have a previously unreported inherited predisposition to urticaria, arthralgia and nephropathy which is distinct from the MWS phenotype.
- Published
- 1996