1. Bone mineral density at extremely low weight in patients with anorexia nervosa
- Author
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Pauline Bemer, Laura Di Lodovico, M. Duquesnoy, Marika Dicembre, Ohanyan Haykanush, Robert Carlier, Karine Briot, Mouna Hanachi, Jean-Claude Melchior, and Hélène Théodon
- Subjects
musculoskeletal diseases ,medicine.medical_specialty ,Pediatrics ,Anorexia Nervosa ,Endocrinology, Diabetes and Metabolism ,Osteoporosis ,030209 endocrinology & metabolism ,Standard score ,03 medical and health sciences ,Absorptiometry, Photon ,0302 clinical medicine ,Endocrinology ,Bone Density ,Internal medicine ,medicine ,Humans ,In patient ,Retrospective Studies ,Femoral neck ,Bone mineral ,business.industry ,musculoskeletal, neural, and ocular physiology ,Retrospective cohort study ,musculoskeletal system ,medicine.disease ,Malnutrition ,medicine.anatomical_structure ,Anorexia nervosa (differential diagnoses) ,030220 oncology & carcinogenesis ,Female ,business - Abstract
OBJECTIVE Low bone mineral density (BMD) is a frequent and invalidating consequence of chronic undernourishment in patients with anorexia nervosa (AN). The aim of this study was to assess prevalence and clinic-biological correlates of low BMD and fractures in extremely undernourished inpatients with AN. DESIGN Retrospective cohort study. PATIENTS AND MEASUREMENTS This study included 97 extremely malnourished female inpatients with AN consecutively admitted over 2 years. Clinical-biological variables, history of fractures and BMD by dual-energy X-ray absorptiometry (DXA) were examined to find predictors of low BMD and fractures. RESULTS The prevalence of low BMD was of 51% for lumbar spine and 38% for femoral neck. Z-scores were lower at lumbar spine (-2.2 ± 1.2 SD) than at femoral neck (-1.9 ± 0.9 SD) (P
- Published
- 2021
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