1. Mesoporous silicon microparticles enhance MHC class I cross-antigen presentation by human dendritic cells.
- Author
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Jiménez-Periáñez A, Abos Gracia B, López Relaño J, Diez-Rivero CM, Reche PA, Martínez-Naves E, Matveyeva E, and Gómez del Moral M
- Subjects
- Antigen-Presenting Cells immunology, Antigens, Viral chemistry, Antigens, Viral immunology, Cells, Cultured, Dendritic Cells metabolism, Epitopes administration & dosage, Epitopes immunology, Humans, Particle Size, Peptide Fragments administration & dosage, Peptide Fragments chemistry, Peptide Fragments immunology, Surface Properties, Antigen Presentation immunology, Calcium Compounds chemistry, Dendritic Cells immunology, Histocompatibility Antigens Class I immunology, Nanoparticles chemistry, Nanoparticles toxicity, Nanoparticles ultrastructure, Silicates chemistry
- Abstract
The mesoporous silicon microparticles (MSMPs) are excellent vehicles for releasing molecules inside the cell. The aim of this work was to use MSMPs to deliver viral specific MHC class I restricted epitopes into human antigen presenting cells (monocyte derived dendritic cells, MDDCs) to facilitate their capture, processing, and presentation to CD8+ (cytotoxic) T lymphocytes. We show for the first time that MSMPs vehiculation of antigenic peptides enhances their MHC class I presentation by human MDDCs to CD8 T lymphocytes.
- Published
- 2013
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