1. Analysis of idiotypic and anti-idiotypic antibodies as models of receptor and ligand.
- Author
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Linthicum DS, Bolger MB, Kussie PH, Albright GM, Linton TA, Combs S, and Marchetti D
- Subjects
- Amino Acid Sequence, Antigens immunology, Antipsychotic Agents immunology, Base Sequence, Binding Sites, Antibody, Computer Simulation, Structure-Activity Relationship, Antibodies, Anti-Idiotypic immunology, Antibodies, Monoclonal genetics, Antibodies, Monoclonal immunology, Immunoglobulin Idiotypes immunology, Models, Biological, Receptors, Drug
- Abstract
Antibodies to small bioactive ligands and peptides may mimic the binding characteristics of the natural receptor; in turn, the anti-idiotypic antibodies generated against the binding sites of such anti-ligand antibodies may mimic some aspects of small bioactive ligands and peptides. Among the several levels of investigation of such antibody-receptor networks are (a) the quantitative structure-activity relationships of ligand binding to antibody as compared with natural receptor; (b) the molecular modeling of antibody-receptor binding sites and the genomic basis for such structures; and (c) the characteristics of the molecular mimicry exhibited by "mimetopes" on anti-idiotypic antibodies. To illustrate the analysis encountered at each of these levels, we discuss here antibody and anti-idiotypic systems that are directed to small neuroactive ligands and their receptors.
- Published
- 1988