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Start Over Author "Yabe, Tomohisa" Journal clinical case reports
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2. Individualized tacrolimus therapy: Insights from CYP3A5 polymorphisms and intestinal metabolism.

Author

Mishima, Mizuki, Yabe, Tomohisa, Kondo, Takaya, Fujimoto, Keiji, Takata, Ryoji, Yokoyama, Hitoshi, Niida, Yo, Tanaka, Tatsuro, Miyazawa, Katsuhito, and Furuichi, Kengo

Subjects
*DRUG monitoring, *CYTOCHROME P-450 CYP3A, *INTESTINAL absorption, *GENETIC polymorphisms, *INTESTINAL mucosa
Abstract

Key Clinical Message: CYP3A4 and CYP3A5 are the most abundant and important enzymes of the CYP3A subfamily, distributed in the liver, intestinal mucosa and kidney, and involved in tacrolimus metabolism. Here, we report a case of tacrolimus dosage refractoriness due to a genetic polymorphism of CYP3A5. [ABSTRACT FROM AUTHOR]

Published
2024
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