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1. Prolonged neuropsychiatric effects following management of chloroquine intoxication with psychotropic polypharmacy

Author

Maxwell, Nicole M, Nevin, Remington L, Stahl, Stephen, Block, Jerald, Shugarts, Sarah, Wu, Alan HB, Dominy, Stephen, Solano-Blanco, Miguel Alonso, Kappelman-Culver, Sharon, Lee-Messer, Christopher, Maldonado, Jose, and Maxwell, Andrew J

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Genetics, Good Health and Well Being, Chloroquine, chronic effects, CYP2D6, genetic polymorphisms, pharmacogenetics, psychosis, quinoline, Agricultural, veterinary and food sciences, Biomedical and clinical sciences, Health sciences
Abstract

Susceptibility to quinoline antimalarial intoxication may reflect individual genetic and drug-induced variation in neuropharmacokinetics. In this report, we describe a case of chloroquine intoxication that appeared to be prolonged by subsequent use of multiple psychotropic medications. This case highlights important new considerations for the management of quinoline antimalarial intoxication.

Published
2015

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