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Your search keyword '"Yamamoto, Shinya"' showing total 2 results
Start Over Author "Yamamoto, Shinya" Publication Year Range Last 3 years Journal clinical case reports
2 results on '"Yamamoto, Shinya"'

1. BRCA2 reversion mutation confers resistance to olaparib in breast cancer.

Author

Yamamoto, Shinya, Kawashima, Kei, Fujiwara, Yoshie, Adachi, Shoko, Narui, Kazutaka, Hosaka, Chiaki, Takahashi, Rina, Tsuyuki, Sho, Sugimori, Makoto, Tanoshima, Miki, Sasamoto, Mahato, Oshi, Masanori, Yamada, Akimitsu, Kunisaki, Chikara, and Endo, Itaru

Subjects
*BRCA genes, *OLAPARIB, *BREAST cancer, *MISSENSE mutation, *GENETIC mutation
Abstract

Key Clinical Message: A rare missense mutation was identified as a reversion mutation using cancer genomic profiling and a suspected mechanism underlying resistance to olaparib in breast cancer. A 34‐year‐old woman with breast cancer and BRCA2: p.Gln3047Ter was treated with olaparib. After tumor progression, cancer genomic profiling testing using liquid biopsy revealed BRCA2 p.Gln3047Ter and p.Gln3047Tyr, with 48.9% and 0.37% allele frequency, respectively. These findings shed light on reversion mutation as a mechanism of resistance to olaparib in breast cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Granulomatous mastitis in a male breast: A case report and review of literature.

Author

Kawashima, Kei, Yamamoto, Shinya, Narui, Kazutaka, Fujiwara, Yoshie, Adachi, Shoko, Sasamoto, Mahato, Oshi, Masanori, Yamada, Akimitsu, Kumagai, Eita, Otani, Masako, and Endo, Itaru

Subjects
*LITERATURE reviews, *MASTITIS, *GYNECOMASTIA, *RARE diseases, *MALES, *MALE infertility
Abstract

Granulomatous mastitis (GM) is a rare disease, particularly among men. Herein, we present a case of GM diagnosed in a 63‐year‐old male patient who showed reduction in the tumor size during 3 months of observation. [ABSTRACT FROM AUTHOR]

Published
2023
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