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Start Over Author "Sang-Jin Han" Journal clinical cardiology
3 results on '"Sang-Jin Han"'

1. Effect of preexisting statin use on expression of C-reactive protein, adhesion molecules, interleukin-6, and antioxidized low-density lipoprotein antibody in patients with unstable angina undergoing coronary stenting

Author

Young-Cheoul Doo, Chong-Yun Rim, Seung-Hyuk Choi, Kyung-Soon Hong, Sang-Jin Han, Yung Lee, Goo Yeong Cho, Dong-Jin Oh, Kwang-Hahk Lee, Sung-Woo Han, Kyu-Hyung Ryu, Kyoo-Rok Han, Woo-Jung Park, and Namho Lee

Subjects
Male, medicine.medical_specialty, Time Factors, Statin, medicine.drug_class, medicine.medical_treatment, Clinical Investigations, Gastroenterology, Statistics, Nonparametric, Group B, chemistry.chemical_compound, Internal medicine, medicine, Humans, Angina, Unstable, cardiovascular diseases, Interleukin 6, Chi-Square Distribution, biology, Interleukin-6, business.industry, Unstable angina, C-reactive protein, Stent, General Medicine, Middle Aged, Intercellular Adhesion Molecule-1, medicine.disease, Coronary Vessels, Lipoproteins, LDL, C-Reactive Protein, chemistry, Low-density lipoprotein, Immunology, biology.protein, Female, Stents, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Cardiology and Cardiovascular Medicine, business, Biomarkers, Lipoprotein
Abstract

Background: Statins are believed to reduce coronary heart disease by mechanisms in addition to their well-known cholesterol lowering effect. Hypothesis: We studied the effect of statins on expression of C-reactive protein (CRP), interleukin-6 (IL-6), adhesion molecules, and antioxidized low-density lipoprotein antibody (anti-oxLDL Ab) in patients with unstable angina (Braunwald class IIb or IIIb) undergoing coronary stenting. Methods: Consecutive 50 patients with unstable angina were included in the study. We classified the study subjects as patients using statins (Group A, n = 20, men 10, mean age 62 years) and patients notusing statins (Group B, n= 30, men 15, mean age 60 years). Results: Baseline levels of inflammatory markers were similar in the two groups. However, 24 h after coronary stenting, serum levels of CRP (2.00 vs. 4.63 mg/l, p < 0.05), intercellular adhesionmolecule-1 (ICAM-1) (217 vs. 261 ng/ml, p

Published
2005

2. Associations between C-reactive protein and circulating cell adhesion molecules in patients with unstable angina undergoing coronary intervention and their clinical implication

Author

Sang-Jin Han, Kwang-Hwahk Lee, Dong-Jin Oh, Seongman Kim, Namho Lee, Kyu-Hyung Ryu, Kyung-Soon Hong, Kyoo-Rok Han, Seung-Hyuk Choi, Goo Yeong Cho, Chong-Yun Rhim, Woo-Jung Park, Yung Lee, and Young-Cheoul Doo

Subjects
medicine.medical_specialty, biology, Cell adhesion molecule, Unstable angina, business.industry, C-reactive protein, Case-control study, General Medicine, medicine.disease, Angina, Internal medicine, medicine, Cardiology, biology.protein, In patient, Risk factor, Cardiology and Cardiovascular Medicine, Risk assessment, business
Abstract

Summary 1.3-3.7, p 321 ng/ml) (OR 1.2, 95% CI 1.1-2.1, p < 0.05) at 72 h after coronary stenting is an inde- pendent risk factor for an adverse cardiac event. Conclusions:These results suggest that in patients with un- stable angina undergoing coronary stenting, the measurements of inflammatory parameters, especially CRP and ICAM-1, may be useful for identifying those at higher risk of a cardiac event, and CRP may play a direct role in promoting the inflam- matory component of atherosclerosis by inducing significant expression of ICAM-1.

Published
2005

3. Associations between C-reactive protein and circulating cell adhesion molecules in patients with unstable angina undergoing coronary intervention and their clinical implication

Author

Young-Cheoul, Doo, Sang-Jin, Han, Woo-Jung, Park, Seong-Man, Kim, Seung-Hyuk, Choi, Goo-Yeong, Cho, Kyung-Soon, Hong, Kyoo-Rok, Han, Nam-Ho, Lee, Dong-Jin, Oh, Kyu-Hyung, Ryu, Chong-Yun, Rhim, Kwang-Hwahk, Lee, and Yung, Lee

Subjects
Male, Myocardial Infarction, Clinical Investigations, Vascular Cell Adhesion Molecule-1, Middle Aged, Intercellular Adhesion Molecule-1, Risk Assessment, Disease-Free Survival, C-Reactive Protein, Death, Sudden, Cardiac, Treatment Outcome, Recurrence, Case-Control Studies, Humans, Female, Stents, Angina, Unstable, E-Selectin, Aged, Follow-Up Studies
Abstract

Background: There is growing evidence that C‐reactive protein (CRP) may have a direct role in the pathogenesis of atherosclerosis. Hypothesis: The purpose of this study was to assess associations between CRP and adhesion molecules and to determine the prognostic value of adhesion molecules as a predictor of cardiac events in patients with unstable angina. Methods: Fifty‐five consecutive patients (33 males, mean age 61 years) with unstable angina (Braunwald class IIb or Ib) undergoing coronary stenting were included in this study. Results: The test for a trend toward increasing intercellular adhesion molecule (ICAM)‐1 concentrations by the 75th percentile of CRP levels at 72 h after coronary stenting was significant (p = 0.03). At 72 h after coronary stenting, CRP levels were the only determinants of ICAM‐1 concentrations by multiple linear regression analysis. An elevated level of CRP (>5.4mg/l) (oddsratio [OR] 1.5,95%confidenceinterval [CI] 1.3–3.7, p321 ng/ml) (OR 1.2, 95% CI 1.1–2.1, p < 0.05) at 72 h after coronary stenting is an independent risk factor for an adverse cardiac event. Conclusions: These results suggest that in patients with unstable angina undergoing coronary stenting, the measurements of inflammatory parameters, especially CRP and ICAM‐1, may be useful for identifying those at higher risk of a cardiac event, and CRP may play a direct role in promoting the inflammatory component of atherosclerosis by inducing significant expression of ICAM‐1.

Published
2005

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