1. Endoglin Targeting in Colorectal Tumor Microenvironment
- Author
-
Lisa M. Becker and Valerie S. LeBleu
- Subjects
0301 basic medicine ,Cancer Research ,Colorectal cancer ,Receptors, Cell Surface ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Antigen ,Cancer-Associated Fibroblasts ,Antigens, CD ,otorhinolaryngologic diseases ,medicine ,Tumor Microenvironment ,Humans ,Receptor ,Colorectal tumor ,Tumor microenvironment ,business.industry ,Endoglin ,Endothelial Cells ,medicine.disease ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,business ,Colorectal Neoplasms - Abstract
On endothelial cells, the TGFβ/BMP-9 coreceptor, endoglin, emerged as a promising antiangiogenic target in colorectal cancer. Its promiscuous expression by cancer-associated fibroblasts (CAF) emerges to facilitate metastasis. The multitarget impact of neutralizing endoglin may offer added benefit in controlling colorectal cancer. See related article by Paauwe et al., p. 6331
- Published
- 2018