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Your search keyword '"Sounira Mehri"' showing total 3 results
Start Over Author "Sounira Mehri" Journal clinical biochemistry
3 results on '"Sounira Mehri"'

2. Association of homocysteine thiolactonase activity and PON1 polymorphisms with the severity of acute coronary syndrome

Author

Sonia Hammami, Sounira Mehri, Nadia Koubaa, Amel Nakbi, Mohamed Ben Farhat, Nabil Attia, Khaldoun Ben Hamda, Abdelhedi Miled, and Mohamed Hammami

Subjects
Male, medicine.medical_specialty, Acute coronary syndrome, Genotype, Apolipoprotein B, Homocysteine, Clinical Biochemistry, Enzyme-Linked Immunosorbent Assay, Coronary Artery Disease, Coronary artery disease, chemistry.chemical_compound, Internal medicine, medicine, Humans, Aged, Polymorphism, Genetic, biology, Aryldialkylphosphatase, business.industry, Cholesterol, Paraoxonase, General Medicine, Middle Aged, medicine.disease, PON1, Lipoproteins, LDL, Endocrinology, chemistry, biology.protein, Female, Gene polymorphism, business
Abstract

Introduction Excess of total homocysteine (tHcy) and decrease of thiolactonase activities (HTase) have been proposed as risk factors for coronary artery diseases (CAD). Objectives We evaluated the relationship of tHcy and HTase with paraoxonase 1 (PON1) gene polymorphism according to CAD severity. Design and methods 118 healthy volunteers and 91 CAD patients were compared. Results Serum levels of tHcy and oxidized LDL (ox-LDL) increased significantly by 26% and 48% in CAD patients and were associated with significantly lower levels of HDL cholesterol (p = 0.02) and 42% of decrease in HTase activities (p

Published
2009

3. Relationship between genetic polymorphisms of angiotensin-converting enzyme and methylenetetrahydrofolate reductase as risk factors for type 2 diabetes in Tunisian patients

Author

Sounira Mehri, Bechir Zouari, Mohamed Abid, Bruno Baudin, Sonia Hammami, Amel Nakbi, Nadia Koubaa, R. Chaaba, Mohamed Hammami, Sinda Zarrouk Mahjoub, and Saïda Ben Arab

Subjects
Adult, Male, medicine.medical_specialty, Diabetes risk, Tunisia, Homocysteine, Genotype, Clinical Biochemistry, Single-nucleotide polymorphism, Type 2 diabetes, Biology, Peptidyl-Dipeptidase A, chemistry.chemical_compound, Risk Factors, Diabetes mellitus, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Methylenetetrahydrofolate Reductase (NADPH2), Aged, Polymorphism, Genetic, Type 2 Diabetes Mellitus, Angiotensin-converting enzyme, General Medicine, Middle Aged, medicine.disease, digestive system diseases, Endocrinology, chemistry, Diabetes Mellitus, Type 2, Methylenetetrahydrofolate reductase, biology.protein, Female
Abstract

The role of methylenetetrahydrofolate reductase (MTHFR) and angiotensin-converting enzyme (ACE) gene polymorphisms as being risk factors for diabetes is still controversial. The aim was to investigate the distribution of ACE and MTHFR genotypes as well as to evaluate the role of plasmatic total homocysteine levels (tHcy) and ACE activity in Tunisian patients with type 2 diabetes mellitus (T2DM).115 T2DM patients compared to 116 healthy volunteers.The ACE I/D polymorphism was significantly associated with diabetes (p0.0001). The DD genotype and D allele were more frequent in patients compared to control group [DD: OR=4.93; p0.0001; 95 % CI: 2.71-8.97; D: OR=3.08, 95% CI: 2.09-4.51 p0.0001]. MTHFR allele and genotype frequencies did not differ between patients and controls. The susceptibility to diabetes in individuals with genotypes DD+vTT was 13.39 and in the individuals with DD+CT was 6.57 times that of the controls. However, individuals with genotypes ID+CC or II+CT have a protective effect against diabetes. The DD and TT genotypes were associated with significantly higher ACE activity and tHcy levels in diabetics.Our data suggest that ACE ID polymorphism may act synergistically with MTHFR C677T polymorphism to assess diabetes risk.

Published
2009

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