1. Serum markers for predicting significant necroinflammatory activity in patients with chronic hepatitis B
- Author
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Young Jip Kim, Sung Won Cho, Jin Mo Yang, Dong Joon Kim, Hyo Jung Cho, Jae Youn Cheong, Ga Won Song, Young Nyun Park, Young Bae Kim, Seung Kyung Lee, Han Gyeol Kim, Seong Gyu Hwang, Seun Joo Ahn, Chang Bum Bae, and Soon Sun Kim
- Subjects
Adult ,Male ,medicine.medical_specialty ,Scoring system ,Adolescent ,Clinical Biochemistry ,Inflammation ,Gastroenterology ,Necrosis ,Young Adult ,Hepatitis B, Chronic ,Chronic hepatitis ,Internal medicine ,medicine ,Humans ,In patient ,Procollagen iii ,Receiver operating characteristic ,business.industry ,General Medicine ,Middle Aged ,Predictive value ,Logistic Models ,ROC Curve ,Immunology ,Multivariate Analysis ,Female ,medicine.symptom ,business ,Biomarkers ,Serum markers - Abstract
Objectives The aim of this study was to determine the serum markers that predict significant inflammation in patients with chronic hepatitis B (CHB). Design and methods Between October 2005 and June 2009, 384 subjects with CHB were enrolled. Results Multiple logistic regression analysis identified the ALT, hyaluronic acid (HA) and procollagen III N-terminal peptide (PIIINP) as independent predictors of significant inflammation (grade ≥ 3). We constructed a formula for predicting significant inflammation. A significant inflammation (SI) score = 1.773 × ALT score + 1.599 × PIIINP score + 0.677 × HA score − 1.962. The area under receiver operating characteristic curve of the SI score was 0.831. The sensitivity, specificity, positive predictive value and negative predictive value of the SI score were 79.5%, 70.8%, 76.8% and 74.3%, respectively. Conclusions A simple scoring system including ALT, PIIINP and HA is an accurate non-invasive predictor of significant inflammatory activities in patients with CHB.
- Published
- 2012