1. Cardiac sympathetic innervation in the MPTP non-human primate model of Parkinson disease
- Author
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Mar Carmona-Abellan, Irene Marcilla, Ivan Martinez-Valbuena, Maria-Rosario Luquin, and Carla DiCaudo
- Subjects
Male ,Primates ,Pathology ,medicine.medical_specialty ,Sympathetic Nervous System ,Neurofilament ,animal diseases ,030204 cardiovascular system & hematology ,Random Allocation ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,medicine ,Animals ,Tyrosine hydroxylase ,Endocrine and Autonomic Systems ,business.industry ,MPTP ,Dopaminergic ,MPTP Poisoning ,Heart ,nervous system diseases ,Disease Models, Animal ,Macaca fascicularis ,medicine.anatomical_structure ,nervous system ,chemistry ,Ventricle ,Peripheral nervous system ,alpha-Synuclein ,cardiovascular system ,Systemic administration ,Synuclein ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces degeneration of dopaminergic neurons and reproduces the motor features of Parkinson disease (PD); however, the effect of MPTP on extranigral structures has been poorly studied. The aim of this research was to study the cardiac sympathetic innervation of control and MPTP-treated monkeys in order to describe the influence of MPTP toxicity on cardiac tissue. Eight monkeys were included in the study and divided into two groups, four monkeys serving as controls and four forming the MPTP group. Sections from the anterior left ventricle were immunohistochemically examined to characterize the sympathetic fibers of cardiac tissue. The intensity of immunoreactivity in the nerve fibers was quantitatively analyzed using ImageJ software. As occurs in PD, the sympathetic peripheral nervous system is affected in MPTP-treated monkeys. The percentage of tyrosine hydroxylase immunoreactive fibers in the entire fascicle area was markedly lower in the MPTP group (24.23%) than the control group (35.27%) (p
- Published
- 2019
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