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Start Over Author "Mouna Stayoussef" Journal clinical and vaccine immunology : cvi
1 results on '"Mouna Stayoussef"'

1. Modulation of type 1 diabetes susceptibility by tumor necrosis factor alpha -308 G/A and lymphotoxin alpha +249 A/G haplotypes and lack of linkage disequilibrium with predisposing DQB1-DRB1 haplotypes in Bahraini patients

Author

Mouna Stayoussef, Khadija Al-Ola, Abduljabbar Al-Abbasi, Haya Khayyat, Fayza A. Al-Jenaidi, Wassim Y. Almawi, and Touhami Mahjoub

Subjects
Microbiology (medical), Lymphotoxin alpha, Adult, Male, Linkage disequilibrium, endocrine system diseases, Adolescent, Genotype, Clinical Biochemistry, Immunology, Biology, Linkage Disequilibrium, Gene Frequency, immune system diseases, HLA-DQ Antigens, Immunology and Allergy, HLA-DQ beta-Chains, Humans, Genetic Predisposition to Disease, Child, Allele frequency, Lymphotoxin-alpha, Polymorphism, Genetic, HLA-DQ Antigen, Tumor Necrosis Factor-alpha, Cellular Immunology, Antibodies, and Mediators of Immunity, Haplotype, nutritional and metabolic diseases, Genotype frequency, Diabetes Mellitus, Type 1, Haplotypes, Child, Preschool, Bahrain, Tumor necrosis factor alpha, Female
Abstract

Tumor necrosis factor alpha (TNF-α) −308 G/A and lymphotoxin alpha (LTα) +249 A/G single-nucleotide polymorphisms were investigated in 228 type 1 diabetes mellitus (T1DM) patients and 240 controls. Only LTα +249G allele and +249G/+249G genotype frequencies were higher among patients, and no linkage disequilibrium was found between TNF-α/LTα alleles and susceptible/protective DRB1-DQB1 haplotypes. TNF-α/LTα T1DM-susceptible (−308G/+249G) and protective (−308G/+249A) haplotypes were identified.

Published
2007

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