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Start Over Author "Reiner Hoppe" Journal clinical and translational science
2 results on '"Reiner Hoppe"'

1. The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)‐Endoxifen in Breast Cancer

Author

Jeanine Marie Nardin, Werner Schroth, Thais Abreu Almeida, Thomas Mürdter, Solane Picolotto, Evelyn Castillo Lima Vendramini, Reiner Hoppe, Jenifer Primon Kogin, Diandra Miqueleto, Silvia Dark Robaskievicz deMoraes, Matthias Schwab, Roberto Flavio Pecoits‐Filho, Hiltrud Brauch, and José Claudio Casali‐da‐Rocha

Subjects
Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270
Abstract

Tamoxifen efficacy in breast cancer is suspected to depend on adherence and intact drug metabolism. We evaluated the role of adherence behavior and pharmacogenetics on the formation rate of (Z)‐endoxifen. In 192 Brazilian patients, we assessed plasma levels of tamoxifen and its metabolites at 3, 6, and 12 months of treatment (liquid‐chromatography tandem mass spectrometry), adherence behavior (Morisky, Green, and Levine medication adherence scale), and cytochrome P450 2D6 (CYP2D6) and other pharmacogene polymorphisms (matrix‐assisted laser‐desorption‐ionization time of flight) mass spectrometry, real‐time polymerase chain reaction). Adherence explained 47% of the variability of tamoxifen plasma concentrations (P

Published
2020
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2. The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)‐Endoxifen in Breast Cancer

Author

Jeanine Marie Nardin, José Cláudio Casali-da-Rocha, Jenifer Primon Kogin, Reiner Hoppe, Thomas E. Mürdter, Hiltrud Brauch, Evelyn Castillo Lima Vendramini, Roberto Pecoits-Filho, Thais Abreu Almeida, Solane Picolotto, Werner Schroth, Diandra Miqueleto, Matthias Schwab, and Silvia Dark Robaskievicz de Moraes

Subjects
Oncology, 030213 general clinical medicine, Pharmacogenomic Variants, 030226 pharmacology & pharmacy, 0302 clinical medicine, General Pharmacology, Toxicology and Pharmaceutics, skin and connective tissue diseases, Aged, 80 and over, General Neuroscience, lcsh:Public aspects of medicine, General Medicine, Articles, Middle Aged, 3. Good health, Cytochrome P-450 CYP2D6, Female, Drug Monitoring, Brazil, medicine.drug, Adult, medicine.medical_specialty, CYP2D6, Antineoplastic Agents, Hormonal, Breast Neoplasms, General Biochemistry, Genetics and Molecular Biology, Article, Medication Adherence, 03 medical and health sciences, Young Adult, Breast cancer, Internal medicine, medicine, Humans, Active metabolite, Aged, business.industry, Research, lcsh:RM1-950, lcsh:RA1-1270, medicine.disease, Confidence interval, Pharmacogenomic Testing, Tamoxifen, lcsh:Therapeutics. Pharmacology, Relative risk, Self Report, business, Pharmacogenetics, Drug metabolism
Abstract

Tamoxifen efficacy in breast cancer is suspected to depend on adherence and intact drug metabolism. We evaluated the role of adherence behavior and pharmacogenetics on the formation rate of (Z)-endoxifen. In 192 Brazilian patients, we assessed plasma levels of tamoxifen and its metabolites at 3, 6, and 12 months of treatment (liquid-chromatography tandem mass spectrometry), adherence behavior (Morisky, Green, and Levine medication adherence scale), and cytochrome P450 2D6 (CYP2D6) and other pharmacogene polymorphisms (matrix-assisted laser-desorption-ionization time of flight) mass spectrometry, real-time polymerase chain reaction). Adherence explained 47% of the variability of tamoxifen plasma concentrations (P

Published
2019

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