1. Integrating phosphoproteomics into the clinical management of prostate cancer
- Author
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Shridar Ganesan, Victor M. Tan, Larry C. Cheng, and Justin M. Drake
- Subjects
0301 basic medicine ,Phosphoproteomics ,Druggability ,Medicine (miscellaneous) ,Computational biology ,Bioinformatics ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,medicine ,Mass spectrometry ,business.industry ,Clinical study design ,Precision medicine ,Cancer ,medicine.disease ,Pharmacotherapy ,3. Good health ,Clinical trial design ,030104 developmental biology ,Targeted mass spectrometry ,Drug development ,Kinase inhibitors ,030220 oncology & carcinogenesis ,Clinical diagnostics ,Commentary ,Molecular Medicine ,business ,Biomarkers - Abstract
Phosphoproteomic analysis of tumor samples has the potential to uncover significant insights into kinase signaling networks present in late stage prostate cancer that are complementary to genomic and transcriptomic approaches. Phosphoproteomics could potentially aid drug development in clinical trial design as well as provide utility for oncologists in the personalized therapeutic management of individual cancers through identifying novel biomarkers and druggable targets. Rapid advancement of targeted mass spectrometry platforms is underway to integrate phosphoproteomic technology with genomic assays to soon translate this information into the cancer clinic.
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