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Your search keyword '"Kim, Soon Sun"' showing total 14 results
Start Over Author "Kim, Soon Sun" Journal clinical and molecular hepatology
14 results on '"Kim, Soon Sun"'

7. Clinical outcomes of transjugular intrahepatic portosystemic shunt for portal hypertension: Korean multicenter real-practice data

Author

Kim, Hyung Ki, primary, Kim, Yoon Jun, additional, Chung, Woo Jin, additional, Kim, Soon Sun, additional, Shim, Jae Jun, additional, Choi, Moon Seok, additional, Kim, Do Young, additional, Jun, Dae Won, additional, Um, Soon Ho, additional, Park, Sung Jae, additional, Woo, Hyun Young, additional, Jung, Young Kul, additional, Baik, Soon Koo, additional, Kim, Moon Young, additional, Park, Soo Young, additional, Lee, Jae Myeong, additional, and Kim, Young Seok, additional

Published
2014
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9. Association between apolipoprotein E genotype, chronic liver disease, and hepatitis B virus

Author

Ahn, Seun Joo, primary, Kim, Dong Kyu, additional, Kim, Soon Sun, additional, Bae, Chang Bum, additional, Cho, Hyo Jung, additional, Kim, Han Gyeol, additional, Kim, Young Jip, additional, Lee, Joo Ho, additional, Lee, Hyo Jin, additional, Lee, Mi Yeon, additional, Kim, Kee Bum, additional, Cho, Jin Hee, additional, Cho, Sung Won, additional, and Cheong, Jae Youn, additional

Published
2012
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11. GULP1 as a Novel Diagnostic and Predictive Biomarker in Hepatocellular Carcinoma.

Author

Kim HS, Yoon JH, Choi JY, Yoon MG, Baek GO, Kang M, Jang SH, Park W, Go Y, Ng JT, Nam SW, Jeong JY, Han JE, Cho HJ, Lim SB, Kim SS, Cheong JY, and Eun JW

Abstract

Backgrounds/aims: Hepatocellular carcinoma (HCC) is characterized by high recurrence and mortality, necessitating the identification of reliable biomarkers. In this study, we aimed to identify the predictive gene signatures for HCC recurrence and evaluate the efficiency of GULP PTB domain-containing engulfment adaptor 1 (GULP1) as a predictive and diagnostic marker and therapeutic target for HCC., Methods: We analyzed genomic datasets from The Cancer Genome Atlas and Gene Expression Omnibus databases via least absolute shrinkage and selection operator Cox regression and 10-fold cross-validation, leading to the development of a 15-gene risk score model, which was validated using three independent datasets. Serum GULP1 and α-fetoprotein levels were assessed to determine the diagnostic accuracy of the model. Using clinical cohorts and patient sera, GULP1 roles were examined, and functional assays in vitro and in vivo were used to evaluate its effects on cell growth, epithelial-mesenchymal transition (EMT), ADP-ribosylation factor 6 activation, and β-catenin signaling., Results: Our newly developed risk-score model accurately predicted recurrent HCC in all datasets. Among the 15 genes in the risk score model, GULP1 was overexpressed in patients with HCC and independently predicted HCC recurrence. Its expression modulation influenced cell growth and EMT, with observed effects on ADP-ribosylation factor 6 activation and β-catenin signaling pathways., Conclusions: GULP1 is a crucial biomarker for HCC, serving as a non-invasive diagnostic and predictive tool. It also plays key roles in HCC progression. Our findings highlight the potential use of GULP1 in treatment strategies targeting EMT and HCC recurrence to improve the personalized care and patient outcomes.

Published
2025
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14. Management of liver diseases during the pandemic of coronavirus disease-19.

Author

Cho JY, Kim SS, Lee YS, Song DS, Lee JH, and Kim JH

Subjects
Antiviral Agents therapeutic use, Betacoronavirus isolation & purification, COVID-19, Carcinoma, Hepatocellular pathology, Carcinoma, Hepatocellular therapy, Coronavirus Infections complications, Coronavirus Infections drug therapy, Coronavirus Infections epidemiology, Cross Infection prevention & control, Drug Interactions, Humans, Immunosuppressive Agents therapeutic use, Liver Diseases complications, Liver Diseases pathology, Liver Neoplasms pathology, Liver Neoplasms therapy, Liver Transplantation, Pandemics, Pneumonia, Viral complications, Pneumonia, Viral drug therapy, Pneumonia, Viral epidemiology, SARS-CoV-2, Coronavirus Infections pathology, Liver Diseases prevention & control, Pneumonia, Viral pathology
Published
2020
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