1. Evaluation of a global screening assay for the investigation of the protein C anticoagulant pathway.
- Author
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Rimmer JE, Cooper PC, Brookfield CJ, Preston FE, and Makris M
- Subjects
- Activated Protein C Resistance blood, Activated Protein C Resistance diagnosis, Blood Coagulation Tests standards, Evaluation Studies as Topic, Female, Humans, Lupus Coagulation Inhibitor blood, Male, Partial Thromboplastin Time, Protein C standards, Protein C Deficiency blood, Protein C Deficiency diagnosis, Reference Values, Sex Factors, Blood Coagulation Tests methods, Protein C analysis
- Abstract
We have evaluated a global screening test for the protein C pathway, the 'ProC Global' (Dade Behring Ltd, Milton Keynes, UK). Patient groups tested included inherited protein C or S deficient and inherited/acquired activated protein C resistance. Results showed that protein C deficiencies and activated protein C resistance could be successfully detected with this test whereas deficiencies of protein S were less readily distinguished from the normal population. The ProC Global was unreliable in patients with antiphospholipid antibodies, raised plasma factor VIII:C and in those receiving oral anticoagulant therapy.
- Published
- 2000
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