1. Congenital Thrombophilia in Patients With Superior Mesenteric Venous Thrombosis or Portal Vein Thrombosis
- Author
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Hidekazu Tomimoto, Hideo Wada, Kaname Nakatani, Ikejiri Makoto, Takeshi Matsumoto, Shuji Isaji, Masanobu Usui, Yoshiki Yamashita, Shigehisa Tamaki, Kohshi Ohishi, and Akihiro Shindo
- Subjects
Adult ,Male ,medicine.medical_specialty ,genetic structures ,030204 cardiovascular system & hematology ,Gene mutation ,medicine.disease_cause ,Thrombophilia ,behavioral disciplines and activities ,Gastroenterology ,Protein S ,superior mesenteric vein thrombosis ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,mental disorders ,medicine ,Humans ,portal vein thrombosis ,Vein ,Aged ,Aged, 80 and over ,Venous Thrombosis ,Mutation ,biology ,Portal Vein ,business.industry ,Antithrombin ,Original Articles ,Hematology ,General Medicine ,Middle Aged ,medicine.disease ,Portal vein thrombosis ,medicine.anatomical_structure ,biology.protein ,Female ,030211 gastroenterology & hepatology ,business ,Protein C ,medicine.drug - Abstract
We explored the relationship between abdominal vein thromboses, including portal vein thrombosis (PVT) and superior mesenteric vein thrombosis (SMVT), and thrombophilia. The frequency of thrombophilia, such as antithrombin (AT), protein C (PC), or protein S (PS) gene mutations, was examined in 21 patients with PVT, 6 patients with SMVT, and 6 patients with both PVT and SMVT. Low levels of AT, PC, or PS were frequently detected in patients with PVT or mesenteric vein thrombosis, and 4 mutations in the PS gene, 3 mutations in the PC gene, and 2 mutations in AT the gene were detected. Protein S Tokushima was detected in 3 of 4 patients with a PS gene mutation and was associated with 2 other PS gene mutations. The onset of PVT or SMVT was almost idiopathic in patients with congenital thrombophilia. Both PVT and SMVT were frequently caused by an AT, a PC, or a PS mutation, and the onset of these thromboses due to thrombophilia was frequently idiopathic.
- Published
- 2018