1. The clinical implications of adult-onset henoch-schonelin purpura.
- Author
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Jithpratuck, Warit, Elshenawy, Yasmin, Saleh, Hana, Youngberg, George, Chi, David S., and Krishnaswamy, Guha
- Subjects
SCHOENLEIN-Henoch purpura ,VASCULITIS ,IMMUNOGLOBULINS ,THROMBOCYTOPENIA ,ABDOMINAL pain ,PURPURA (Pathology) ,ARTHRITIS - Abstract
Henoch-Schonlein Purpura (HSP) is a small vessel vasculitis mediated by IgA-immune complex deposition. It is characterized by the clinical tetrad of non-thrombocytopenic palpable purpura, abdominal pain, arthritis and renal involvement. Pathologically, it can be considered a form of immune complex-mediated leukocytoclastic vasculitis (LCV) involving the skin and other organs. Though it primarily affects children (over 90% of cases), the occurrence in adults has been rarely reported. Management often involves the use of immunomodulatory or immune-suppressive regimens. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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