1. INHIBITORY EFFECT OF NITRIC OXIDE ON THE RENIN–ANGIOTENSIN SYSTEM IN DAHL SALT-SENSITIVE RATS.
- Author
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Kasuya, Akira, Satoh, Sachi, Yoshida, Makoto, Hisa, Hiroaki, Suzuki-Kusaba, Mizue, and Satoh, Susumu
- Subjects
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NITRIC oxide , *RENIN , *ANGIOTENSINS , *PHYSIOLOGY - Abstract
SUMMARY1. To explore the role of nitric oxide (NO) in the regulation of the renin–angiotensin system (RAS) in Dahl salt-sensitive (DS) rats, the effects of NG-nitro-L-arginine methyl ester (L-NAME) on plasma renin activity (PRA), and concentrations of angiotensin (Ang)I and AngII in the plasma, aorta and kidney were investigated in DS and Dahl salt-resistant (DR) rats. 2. NG-Nitro-L-arginine methyl ester (12–18 mg/kg per day) administration for 1 week increased mean arterial pressure (MAP) in DS and DR rats fed a 0.3% NaCl diet and in DR rats fed an 8% NaCl diet compared with corresponding vehicle (water)-treated groups. However, L-NAME administration did not change MAP in DS rats fed an 8% NaCl diet. 3. NG-Nitro-L-arginine methyl ester administration increased PRA in DS rats fed an 8% NaCl diet, but not in DR rats fed an 8% NaCl diet. NG-Nitro-L-arginine methyl ester administration increased AngI and AngII concentrations in plasma, aorta and kidney only in DS rats fed an 8% NaCl diet. The ratio of AngI to AngII did not change following L-NAME administration in any rats. 4. These results suggest that NO has an inhibitory role on renin release in DS rats fed a high-salt diet. [ABSTRACT FROM AUTHOR]
- Published
- 1999
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