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Summary: Intermittent inflammation of the vulval pilosebaceous units is common and usually self‐limiting, but some patients experience recurrent and more troublesome symptoms. There is a scarcity of information on this problem. We describe the clinical and histological features in these patients and the response to treatment. A retrospective, observational study of 16 patients with this phenomenon of recurrent, protracted folliculocentric inflammation of the vulval pilosebaceous unit was performed. Details on the clinical features, histology and response to treatment were collected. Mean age at presentation was 32 years (range 21–45). All patients reported recurrent painful papules and pustules on the labia majora and labia minora. Nine patients reported a cyclical pattern to the development of lesions, with premenstrual exacerbation being most common. Histological examination of these lesions showed a folliculocentric microabscess formation surrounded by an acute and chronic inflammatory cell infiltrate, with a focal foreign‐body granulomatous reaction. All our patients responded well to tetracycline, antiandrogenic or retinoid therapy. We propose the term 'vulval acne' for this condition and propose a stepwise approach to its management. We hope to highlight this as a common but underreported entity. [ABSTRACT FROM AUTHOR]

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A 55-year-old man with a history of mild psoriasis was started on imatinib for chronic myeloid leukaemia. He developed new nail dystrophy after treatment with an exacerbation of his psoriasis. Although not a contraindication for this drug, it should be remembered that psoriasis may worsen with imatinib. [ABSTRACT FROM AUTHOR]

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Anti-tumour necrosis factor-α therapy of Crohn's disease (CD) with infliximab has proved a major advance in the treatment of patients with difficult disease. We report our experience of the use of infliximab in a patient with recalcitrant vulval CD. The introduction of infliximab has improved disease control, although a search for an optimum remittive dosing schedule is ongoing. [ABSTRACT FROM AUTHOR]

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Summary: Vulval basal cell carcinomas (BCCs) are rare, representing < 5% of vulval malignancies and 1% of all BCCs. They often present with nonspecific symptoms and features that lead to large, poorly circumscribed and late‐presenting lesions. Current and conventional treatments used to treat vulval BCC include cryotherapy, imiquimod and excision. However, recurrence rates as high as 20% have been reported with these treatments. Furthermore, there are no current clinical guidelines for their management. We present the first reported series of patients with vulval BCC treated with Mohs micrographic surgery (MMS). We report seven cases of vulval BCC treated with MMS at a tertiary referral centre over 3 years. Follow‐up was performed at 3 months and up to 3 years. Our series demonstrates that there were no postoperative complications, functional sequelae or recurrences up to the 3‐year follow‐up. We therefore recommend that MMS should be considered in the management of vulval BCCs. [ABSTRACT FROM AUTHOR]

The article discusses the views of the patients and clinicians on vulval melanoma case. The patient shared her experience of having diagnosed with prolapsed urethra and was prescribed with different cream by her surgeon. Clinicians believes that the treatment of vulval melanoma was through wide surgical excision and the survival rate of patients is only for five years.

The article presents a clinical case of a 27-year-old woman who was found to have unusual vulval papules. She was referred with a 4-year history of asymptomatic vulval lesions, genital warts, and cervical intraepithelial neoplasia which were treated through laser ablation. Histological findings revealed numerous ductal structures surrounded by sclerotic stroma. Her condition was diagnosed with multiple epidermoid cysts, Fox-Fordyce disease, steatocystoma, and atypical genital warts.