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Levamisole (an increasingly frequent contaminant of cocaine) can cause antineutrophil cytoplasmic antibody-associated vasculitis. Dermatologists should consider a diagnosis of cocaine/levamisole-associated cutaneous vasculopathy syndrome in cases of purpura of the ears and/or extensive retiform purpura in drug users. We report a case of particularly severe levamisole-induced necrotic purpura and immunological abnormalities in a 40-year-old woman. [ABSTRACT FROM AUTHOR]

A 70-year-old man was admitted with a 20-year history of multiple cutaneous vascular malformations that had progressively appeared over the face and the trunk (Fig.). Full-body computed tomography (CT) scan showed three cerebral nodules, measuring 7, 4 and 3 mm, respectively, in the frontal lobe, several hepatic lesions in liver segments IV, V and VII, and a para-aortic malformation measuring 25 mm in size. The diagnosis of FCC should be considered in patients with multiple vascular malformations, neurological and/or ophthalmological symptoms, and a positive family history of cerebral cavernomas. [Extracted from the article]

Acute generalized exanthematous pustulosis ( AGEP) is a severe adverse cutaneous reaction, which is mostly due to drugs, but which has also been described as occurring after infections. We report a case of severe AGEP with extensive blistering mimicking toxic epidermal necrolysis ( TEN) in a 47-year-old woman. This was associated with a life-threatening primary mumps infection, complicated by perimyocarditis and encephalitis. The recent increase in the incidence of mumps should lead physicians to be aware of the uncommon clinical features and complications of this disease. [ABSTRACT FROM AUTHOR]

The article presents an association between erythema elevatum diutinum and chronic lymphocytic leukaemia. Erythema elevatum diutinum is characterized histologically by a leucocytoctastic vasculitis and the presence of a marked polymorphonuclear leucocyte infiltrate has made some authors classify it with the neutrophilic dermatoses. Haematological abnormalities and inflammatory bowel disease have been described in association with neutrophilic dermatoses as well as with erythema elevatum diutinum and leucocytoclastic vasculius can be associated with malignant blood diseases.