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Start Over Author "Desole, Ms" Journal clinica terapeutica
5 results on '"Desole, Ms"'

1. [Cadmium-induced changes in the activity of the dopaminergic and purinergic systems and in ascorbic acid catabolism in the rat striatum].

Author

Desole MS, Miele M, Esposito G, Fresu L, Enrico P, De Natale G, Anania V, and Miele E

Subjects
Adenosine metabolism, Animals, Corpus Striatum metabolism, Dopamine metabolism, Male, Rats, Receptors, Dopamine metabolism, Receptors, Purinergic metabolism, Uric Acid metabolism, Ascorbic Acid metabolism, Cadmium toxicity, Cadmium Compounds, Corpus Striatum drug effects, Receptors, Dopamine drug effects, Receptors, Purinergic drug effects, Sulfates
Abstract

Levels of dopamine (DA), 3-4-dihydroxyphenylacetic acid (DOPAC), ascorbic acid (AA), dehydroascorbic acid (DHAA), uric acid (UA) and adenosine (ADO), were determined by HPLC in the striatum of male Wistar rats treated with repeated injections of cadmium (as sulfate) 3 mg/kg/day s.c. for 10 consecutive days. Cadmium treatment significantly reduced DOPAC levels with consequent decrease of the DOPAC/DA ratio; AA levels were significantly reduced, while DHAA levels were significantly increased, with consequent increase of DHAA/AA ratio: levels of UA and ADO were both significantly increased. It is concluded that cadmium, given systemically, reduces dopaminergic system activity in the rat striatum; such impairment occurs together with an increase of AA oxidation and of markers of purinergic system activity. The inhibition of striatal dopaminergic activity could be considered the neurochemical basis of behavioral changes induced by cadmium, while the increase of AA oxidation and of purinergic system activity could be considered an antitoxic metabolic response.

Published
1991

2. [Selective pharmacological changes of regional ascorbic acid metabolism in the brain].

Author

Miele M, Desole MS, Enrico P, and Miele E

Subjects
Analysis of Variance, Animals, Apomorphine pharmacology, Ascorbic Acid blood, Brain drug effects, Dextroamphetamine pharmacology, Haloperidol antagonists & inhibitors, Haloperidol pharmacology, Liver metabolism, Male, Rats, Rats, Inbred Strains, Tissue Distribution, Ascorbic Acid metabolism, Brain metabolism
Abstract

A growing body of evidence indicates for ascorbate a very important role in CNS functioning, rather than just fulfilling the relatively passive roles of general reducing agent and enzymatic cofactor. On-going modulation of synaptic events, locomotor activity, intermodulation with the consciousness state, are new fields of ascorbate activity. Several CNS drugs, according to their kind of activity, induce increase or decrease of extracellular brain ascorbate levels; moreover, they can, like d-amphetamine, activate the ascorbate transport system to CNS. Also regional brain ascorbate metabolism can be selectively activated by drugs. Activation of postsynaptic dopaminergic receptors increases ascorbate oxidation in striatum, but not in hypothalamus. Finally, the active transport of ascorbate to neural tissue and its efficient homeostatic system limit the ascorbate therapeutic potential on CNS.

Published
1990

3. [Effects of clofibrate on allyl alcohol poisoning in the rat].

Author

Desole MS, Anania V, Siri R, Esposito G, Fighetti MA, and Miele E

Subjects
1-Propanol poisoning, Alcoholic Intoxication metabolism, Animals, Humans, Liver drug effects, Liver Function Tests, Male, Rats, Clofibrate pharmacology, Liver metabolism, Propanols
Published
1985

4. [Evaluation of the combination of atenolol and indapamide in the therapy of arterial hypertension (with data concerning toxicity and tolerance in the experimental animal)].

Author

Anania V, Bartoli E, Desole MS, Faedda R, Miele E, Olmeo NA, Satta A, Soggia G, and Vacca R

Subjects
Adult, Aged, Animals, Atenolol adverse effects, Blood Pressure drug effects, Body Weight drug effects, Dogs, Drug Therapy, Combination, Electrolytes blood, Female, Hemodynamics drug effects, Humans, Indapamide adverse effects, Male, Middle Aged, Rats, Atenolol administration & dosage, Diuretics administration & dosage, Hypertension drug therapy, Indapamide administration & dosage, Propanolamines administration & dosage
Published
1981

5. [New views on the role of ascorbic acid in the central nervous system].

Author

Miele M, Desole MS, Demontis P, and Bozzo C

Subjects
Amphetamine antagonists & inhibitors, Amphetamine pharmacology, Animals, Antipsychotic Agents administration & dosage, Ascorbic Acid administration & dosage, Behavior, Animal drug effects, Brain drug effects, Cats, Drug Synergism, Drug Therapy, Combination, Female, Guinea Pigs, Humans, Male, Mental Disorders drug therapy, Mental Disorders metabolism, Mice, Rabbits, Rats, Ascorbic Acid pharmacology, Brain metabolism
Published
1988

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