1. Serum bile acid levels in pregnancy with pruritus (bii.e acids and steroids 158)
- Author
-
Kerstin Sjövall and J. Sjövall
- Subjects
medicine.medical_specialty ,Chromatography, Gas ,medicine.drug_class ,Clinical Biochemistry ,In Vitro Techniques ,digestive system ,Biochemistry ,Bile Acids and Salts ,chemistry.chemical_compound ,Pregnancy ,Internal medicine ,medicine ,Humans ,Bile acid ,Chemistry ,Pruritus ,Biochemistry (medical) ,Cholic acid ,Conjugated bile acids ,General Medicine ,medicine.disease ,Pregnancy Complications ,Blood ,Endocrinology ,Chemistry, Clinical ,Female - Abstract
The serum bile acid levels in 22 healthy pregnant women have been studied with gas-liquid chromatography. The mean concentration of total bile acids was 0.087 mg% (not corrected for 15–40% loss of bile acids in the purification of the scrum extracts). The mean ratios between deoxycholic, chenodeoxycholic and cholic acids were 0.9:1.0:1.0 and only conjugated bile acids could be found. In six cases with pruritus in the last trimester, the mean concentration of total serum bile acids was 2.48 mg%. The mean ratios between deoxycholic, chenodeoxycholic and cholic acids were 0.1:1.0:4.5. Except for traces of free bile acids in one subject, all bile acids were conjugated. Significant amounts of bile acids other than those mentioned were not found.
- Published
- 1966