1. Oxidative status in patients submitted to conization and radiation treatments for uterine cervix neoplasia
- Author
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Maria Rosa Chitolina Schetinger, Maria do Carmo Araújo, Luiz Augusto Negrini, Paula Acosta Maldonado, Rafael Fernandes Zanin, Rosilene Rodrigues Kaizer, Vera Maria Morsch, and Vanessa Battisti
- Subjects
Adult ,medicine.medical_specialty ,Pathology ,Antioxidant ,Protein Carbonyl Content ,medicine.medical_treatment ,Clinical Biochemistry ,Conization ,Uterine Cervical Neoplasms ,Biochemistry ,Gastroenterology ,Thiobarbituric Acid Reactive Substances ,Lipid peroxidation ,Protein Carbonylation ,chemistry.chemical_compound ,Internal medicine ,medicine ,TBARS ,Humans ,Aged ,Cervical cancer ,biology ,Chemistry ,Biochemistry (medical) ,General Medicine ,Glutathione ,Blood Proteins ,Middle Aged ,medicine.disease ,Catalase ,Uterine Cervical Dysplasia ,Squamous intraepithelial lesion ,biology.protein ,Carcinoma, Squamous Cell ,Female ,Lipid Peroxidation ,Oxidation-Reduction ,Biomarkers - Abstract
Background Cervical cancer is a major cause of morbidity among women. We investigated the treatment effect on oxidative status from patients submitted to radiotherapy or conization surgery to high-grade SIL (squamous intraepithelial lesion) treatment, and oxidative profile from patients newly diagnosed for uterine cervix cancer, without treatment. Methods We determined the catalase activity in blood, reduced glutathione (GSH) in plasma, TBARS and protein carbonyl content from serum samples of the patients. Results The catalase activity, GSH levels, TBARS and protein carbonyl content had no statistical differences related to the controls, neither when the 2 treatments were compared, possibly because the antioxidant defense may be acting in the first period of the neoplasic transformation, and maybe indicating a possible arrest of the tumor cells caused by the efficiency of the treatments. In the non-treated patients, TBARS and protein carbonyl contents, GSH levels and catalase activity were shown to be increased comparing with the treated patients and compared with the controls indicating an tumor effect on oxidative profile, and the antioxidant activity been increased in the beginning of the tumor development. Conclusions We suggest that the treatments were efficient in arrest of the tumor.
- Published
- 2005