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In 2021, the Yangtze–Huaihe River Basin (YHRB) of China underwent normal precipitation during the classical Meiyu period in June–July but suffered extreme precipitation and severe floods in August. The present study revealed that the extreme heavy precipitation anomalies over the YHRB region were closely related to the combined effect of the strong western North Pacific anomalous anticyclone (WNPAC) and East Asian middle–high latitude circulation anomalies in August 2021. Moreover, the background of sea surface temperature (SST) anomalies was a strong eastern-Pacific La Niña event that rapidly decayed in spring and a second La Niña emerged in late summer, accompanied by a weak tropical Indian Ocean warming and a strong tropical Atlantic warming in summer. The rapidly decaying La Niña event and the weak tropical Indian Ocean warming alone seem to be insufficient to induce the strong WNPAC in August 2021. Observational evidence and numerical experiments suggest that the rapid tropical Atlantic warming from late spring to summer observably contributed to the enhancement and westward shift of the WNPAC, and the cold SST anomalies in the eastern tropical Pacific associated with the second La Niña event also provided favorable conditions for a strong WNPAC in August 2021. Overall, rapid tropical Atlantic warming and the development of the second La Niña contributed to the strong WNPAC in August 2021, while the maintenance mechanism of the East Asian middle–high latitude circulation anomalies that controlled cold air activity remains unclear. [ABSTRACT FROM AUTHOR]