1. Differences in Metabolomic Profiles Between Black and White Women and Risk of Coronary Heart Disease: an Observational Study of Women From Four US Cohorts
- Author
-
Hu, Jie, Yao, Jie, Deng, Shuliang, Balasubramanian, Raji, Jiménez, Monik C, Li, Jun, Guo, Xiuqing, Cruz, Daniel E, Gao, Yan, Huang, Tianyi, Zeleznik, Oana A, Ngo, Debby, Liu, Simin, Rosal, Milagros C, Nassir, Rami, Paynter, Nina P, Albert, Christine M, Tracy, Russell P, Durda, Peter, Liu, Yongmei, Taylor, Kent D, Johnson, W Craig, Sun, Qi, Rimm, Eric B, Eliassen, A Heather, Rich, Stephen S, Rotter, Jerome I, Gerszten, Robert E, Clish, Clary B, and Rexrode, Kathryn M
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Heart Disease - Coronary Heart Disease ,Atherosclerosis ,Aging ,Cardiovascular ,Prevention ,Clinical Research ,Heart Disease ,Good Health and Well Being ,Amino Acids ,Coronary Disease ,Female ,Hormones ,Humans ,Lipids ,Risk Factors ,United States ,heart diseases ,health status disparities ,metabolomics ,plasma ,race ,women ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
BackgroundRacial differences in metabolomic profiles may reflect underlying differences in social determinants of health by self-reported race and may be related to racial disparities in coronary heart disease (CHD) among women in the United States. However, the magnitude of differences in metabolomic profiles between Black and White women in the United States has not been well-described. It also remains unknown whether such differences are related to differences in CHD risk.MethodsPlasma metabolomic profiles were analyzed using liquid chromatography-tandem mass spectrometry in the WHI-OS (Women's Health Initiative-Observational Study; 138 Black and 696 White women), WHI-HT trials (WHI-Hormone Therapy; 156 Black and 1138 White women), MESA (Multi-Ethnic Study of Atherosclerosis; 114 Black and 219 White women), JHS (Jackson Heart Study; 1465 Black women with 107 incident CHD cases), and NHS (Nurses' Health Study; 2506 White women with 136 incident CHD cases). First, linear regression models were used to estimate associations between self-reported race and 472 metabolites in WHI-OS (discovery); findings were replicated in WHI-HT and validated in MESA. Second, we used elastic net regression to construct a racial difference metabolomic pattern (RDMP) representing differences in the metabolomic patterns between Black and White women in the WHI-OS; the RDMP was validated in the WHI-HT and MESA. Third, using conditional logistic regressions in the WHI (717 CHD cases and 719 matched controls), we examined associations of metabolites with large differences in levels by race and the RDMP with risk of CHD, and the results were replicated in Black women from the JHS and White women from the NHS.ResultsOf the 472 tested metabolites, levels of 259 (54.9%) metabolites, mostly lipid metabolites and amino acids, significantly differed between Black and White women in both WHI-OS and WHI-HT after adjusting for baseline characteristics, socioeconomic status, lifestyle factors, baseline health conditions, and medication use (false discovery rate
- Published
- 2022