1. Left Atrial Localized Low-Voltage Areas Indicate Whole Left Atrial Electrophysiological Degeneration in Atrial Fibrillation Patients
- Author
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Toshiaki Mano, Yasuhiro Matsuda, Takuya Tsujimura, Takashi Kanda, Osamu Iida, Masaharu Masuda, Yosuke Hata, Hiroyuki Uematsu, Takayuki Ishihara, Kiyonori Nanto, Shin Okamoto, Naoya Kurata, and Mitsutoshi Asai
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Action Potentials ,Degeneration (medical) ,Nerve conduction velocity ,Pulmonary vein ,Recurrence ,Left atrial ,Internal medicine ,Atrial Fibrillation ,Humans ,Medicine ,Heart Atria ,business.industry ,Atrial fibrillation ,General Medicine ,medicine.disease ,Ablation ,Electrophysiology ,Catheter Ablation ,Cardiology ,Atrial Function, Left ,Electrophysiologic Techniques, Cardiac ,Cardiology and Cardiovascular Medicine ,business ,Low voltage - Abstract
Background: The efficacy of ablation targeting low-voltage areas (LVAs) is controversial, although LVA presence is well known to be associated with AF recurrence after ablation. Atrial fibrillation (AF) substrate may not localize within LVAs. Methods and results: This observational study enrolled 405 consecutive patients who underwent an initial AF ablation procedure. The left atrial voltage map was obtained after pulmonary vein isolation. LVAs were defined as areas with voltage < 0.5 mV. To estimate whole atrial electrophysiological degeneration, mean regional voltage at each of 6 regions and left atrial total conduction velocity were measured. LVAs existed in 143 of 405 (35.3%) patients. Patients with LVAs demonstrated lower mean regional voltages throughout all 6 regions than those without LVAs (1.3 [1.8, 0.8] vs. 0.6 [1.0, 0.2] for anterior wall, p
- Published
- 2022
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