Search

Your search keyword '"Versaci, F"' showing total 5 results
Start Over Author "Versaci, F" Journal circulation
5 results on '"Versaci, F"'

4. Ischemic preconditioning during coronary angioplasty is prevented by glibenclamide, a selective ATP-sensitive K+ channel blocker

Author

Fabrizio Tomai, Luigi Chiariello, Filippo Crea, Francesco Versaci, Achille Gaspardone, Pier A. Gioffrè, A Penta de Peppo, R. De Paulis, Tomai, F, Crea, F, Gaspardone, A, Versaci, F, DE PAULIS, R, PENTA DE PEPPO, Alfonso, Chiariello, L, and Gioffre, Pa

Subjects
Blood Glucose, Male, medicine.medical_treatment, Ischemia, Myocardial Ischemia, Placebo, Glibenclamide, Electrocardiography, Adenosine Triphosphate, Physiology (medical), Angioplasty, Coronary Circulation, Glyburide, Medicine, Humans, Single-Blind Method, Angioplasty, Balloon, Coronary, Saline, Monitoring, Physiologic, medicine.diagnostic_test, business.industry, Vascular disease, Middle Aged, medicine.disease, Calcium Channel Blockers, Anesthesia, Ischemic preconditioning, Female, Calcium Channels, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

BACKGROUND Brief episodes of ischemia render the heart more resistant to subsequent ischemia; this phenomenon has been called ischemic preconditioning. In some animal species, myocardial preconditioning appears to be due to activation of ATP-sensitive K+ (KATP) channels. The role played by KATP channels in preconditioning in humans remains unknown. The aim of this study was to establish whether glibenclamide, a selective KATP channel blocker, abolishes the ischemic preconditioning observed in humans during coronary angioplasty following repeated balloon inflations. METHODS AND RESULTS Twenty consecutive patients undergoing one-vessel coronary angioplasty were randomized to receive 10 mg oral glibenclamide or placebo. Sixty minutes after glibenclamide or placebo administration, patients were given an infusion of 10% dextrose (8 mL/min) to correct glucose plasma levels or, respectively, an infusion of saline at the same infusion rate. Thirty minutes after the beginning of the infusion, both patient groups underwent coronary angioplasty. The mean values (+/- 1 SD) of ST-segment shifts on the surface 12-lead ECG and the intracoronary ECG were measured at the end of the first and second balloon inflations, both 2 minutes long. In glibenclamide-treated patients, the mean ST-segment shift during the second balloon inflation was similar to that observed during the first inflation (23 +/- 13 versus 20 +/- 8 mm, P = NS), and the severity of cardiac pain was greater (55 +/- 21 versus 43 +/- 23 mm on a scale of 0 to 100, P < .05). Conversely, in placebo-treated patients the mean ST-segment shift during the second inflation was less than that during the first inflation (9 +/- 5 versus 23 +/- 13 mm, P < .001), as was the severity of cardiac pain (15 +/- 15 versus 42 +/- 19 mm, P < .01). Blood glucose levels were significantly reduced 60 minutes after glibenclamide compared with those at baseline (53 +/- 9 versus 102 +/- 10 mg/100 mL, P < .001) in the glibenclamide group; however, before coronary angioplasty, blood glucose levels increased to 95 +/- 19 mg/100 mL, a value similar to that found in placebo group (96 +/- 11 mg/100 mL, P = NS). CONCLUSIONS In humans, ischemic preconditioning during brief repeated coronary occlusions is completely abolished by pretreatment with glibenclamide, thus suggesting that it is mainly mediated by KATP channels.

Published
1994

5. Phentolamine prevents adaptation to ischemia during coronary angioplasty: role of alpha-adrenergic receptors in ischemic preconditioning.

Author

Tomai F, Crea F, Gaspardone A, Versaci F, Ghini AS, De Paulis R, Chiariello L, and Gioffrè PA

Subjects
Adrenergic alpha-Antagonists administration & dosage, Adult, Aged, Blood Flow Velocity drug effects, Coronary Circulation drug effects, Electrocardiography drug effects, Female, Humans, Infusions, Intravenous, Male, Middle Aged, Pain, Phentolamine administration & dosage, Receptors, Adrenergic, alpha physiology, Ultrasonography, Interventional, Adrenergic alpha-Antagonists therapeutic use, Angioplasty, Balloon, Coronary, Coronary Disease therapy, Ischemic Preconditioning, Phentolamine therapeutic use
Abstract

Background: Experimental studies indicate that alpha-adrenergic receptors are involved in ischemic preconditioning. Their role in humans is unknown., Methods and Results: Eighteen patients undergoing angioplasty for an isolated stenosis of the left anterior descending coronary artery were randomized to receive intravenous infusion of phentolamine or placebo during the procedure. Intracoronary ECG and cardiac pain were determined at the end of the first two balloon inflations. Average peak velocity in the contralateral coronary artery during balloon occlusion, an index of collateral recruitment, was also assessed by using a Doppler guide wire. In both phentolamine- and placebo-treated patients, average peak velocity significantly increased from baseline to the end of the first inflation (P<.01), but it did not show any further increase during the second inflation. In phentolamine-treated patients, ST-segment changes and cardiac pain severity during the second inflation were similar to those observed during the first inflation (13+/-9 versus 12+/-8 mm, P=NS, and 51+/-34 versus 54+/-32 mm, P=NS, respectively), whereas in placebo-treated patients, they were significantly less (6+/-4 versus 13+/-7 mm, P<.01, and 26+/-20 versus 49+/-22 mm, P<.05, respectively)., Conclusions: The adaptation to ischemia observed in humans after two sequential coronary balloon inflations is abolished by phentolamine and is independent of collateral recruitment. Thus, it occurs due to ischemic preconditioning and is, at least in part, mediated by alpha-adrenergic receptors.

Published
1997
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results