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Your search keyword '"Schrader, Jürgen"' showing total 17 results
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17 results on '"Schrader, Jürgen"'

1. CD73 on T Cells Orchestrates Cardiac Wound Healing After Myocardial Infarction by Purinergic Metabolic Reprogramming

Author

Borg, Nadine, primary, Alter, Christina, additional, Görldt, Nicole, additional, Jacoby, Christoph, additional, Ding, Zhaoping, additional, Steckel, Bodo, additional, Quast, Christine, additional, Bönner, Florian, additional, Friebe, Daniela, additional, Temme, Sebastian, additional, Flögel, Ulrich, additional, and Schrader, Jürgen, additional

Published
2017
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2. Noninvasive Imaging of Early Venous Thrombosis by 19 F Magnetic Resonance Imaging With Targeted Perfluorocarbon Nanoemulsions

Author

Temme, Sebastian, primary, Grapentin, Christoph, additional, Quast, Christine, additional, Jacoby, Christoph, additional, Grandoch, Maria, additional, Ding, Zhaoping, additional, Owenier, Christoph, additional, Mayenfels, Friederike, additional, Fischer, Jens W., additional, Schubert, Rolf, additional, Schrader, Jürgen, additional, and Flögel, Ulrich, additional

Published
2015
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4. Cardiac Myocyte–Specific Expression of Inducible Nitric Oxide Synthase Protects Against Ischemia/Reperfusion Injury by Preventing Mitochondrial Permeability Transition

Author

West, Matthew B., primary, Rokosh, Gregg, additional, Obal, Detlef, additional, Velayutham, Murugesan, additional, Xuan, Yu-Ting, additional, Hill, Bradford G., additional, Keith, Rachel J., additional, Schrader, Jürgen, additional, Guo, Yiru, additional, Conklin, Daniel J., additional, Prabhu, Sumanth D., additional, Zweier, Jay L., additional, Bolli, Roberto, additional, and Bhatnagar, Aruni, additional

Published
2008
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7. Survivin Determines Cardiac Function by Controlling Total Cardiomyocyte Number

Author

Levkau, Bodo, primary, Schäfers, Michael, additional, Wohlschlaeger, Jeremias, additional, von Wnuck Lipinski, Karin, additional, Keul, Petra, additional, Hermann, Sven, additional, Kawaguchi, Naomasa, additional, Kirchhof, Paulus, additional, Fabritz, Larissa, additional, Stypmann, Jörg, additional, Stegger, Lars, additional, Flögel, Ulrich, additional, Schrader, Jürgen, additional, Fischer, Jens W., additional, Hsieh, Patrick, additional, Ou, Yen-Ling, additional, Mehrhof, Felix, additional, Tiemann, Klaus, additional, Ghanem, Alexander, additional, Matus, Marek, additional, Neumann, Joachim, additional, Heusch, Gerd, additional, Schmid, Kurt W., additional, Conway, Edward M., additional, and Baba, Hideo A., additional

Published
2008
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17. Cardiospecific overexpression of the prostaglandin EP3 receptor attenuates ischemia-induced myocardial injury.

Author

Martin M, Meyer-Kirchrath J, Kaber G, Jacoby C, Flögel U, Schrader J, Rüther U, Schrör K, and Hohlfeld T

Subjects
Adrenergic beta-Antagonists pharmacology, Animals, Coronary Circulation, GTP-Binding Protein alpha Subunits, Gi-Go physiology, Magnetic Resonance Imaging, Mice, Mice, Inbred C3H, Mice, Inbred C57BL, Protein Kinase C physiology, Receptors, Prostaglandin E genetics, Receptors, Prostaglandin E, EP3 Subtype, Signal Transduction, Sodium-Hydrogen Exchangers physiology, Transgenes, Ventricular Function, Left, Myocardial Ischemia metabolism, Myocardial Reperfusion Injury prevention & control, Receptors, Prostaglandin E physiology
Abstract

Background: The generation of prostaglandin E2 (PGE2) is significantly increased in acute myocardial ischemia and reperfusion. PGE2, in addition to other prostaglandins, protects the reperfused ischemic myocardium. It has been hypothesized that this cardioprotection is mediated by E-type prostaglandin receptors of the Gi-coupled EP3 subtype., Methods and Results: We tested this hypothesis by generating transgenic (tg) mice with cardiospecific overexpression of the EP3 receptor. According to ligand binding, a 40-fold overexpression of the EP3 receptor was achieved in membranes prepared from tg hearts compared with wild-type (wt) littermates. In isolated cardiomyocytes from tg mice, the forskolin-induced rise in cAMP was markedly attenuated, indicating coupling of the overexpressed EP3 receptor to inhibitory G proteins (Gi) with constitutive receptor activity. There was no evidence for EP3 receptor coupling to Gq-mediated protein kinase C signaling. Isolated hearts from tg and wt mice were subjected to 60 minutes of no-flow ischemia and 45 minutes of reperfusion. In tg hearts, ischemic contracture was markedly delayed compared with wt hearts, and the ischemia-induced increase in left ventricular end-diastolic pressure was reduced by 55%. Creatine kinase and lactate dehydrogenase release was significantly decreased by 85% and 73%, respectively, compared with wt hearts., Conclusions: Constitutive prostaglandin EP3 receptor signaling exerts a protective effect on cardiomyocytes, which is probably Gi mediated and results in a remarkable attenuation of myocardial injury during ischemia and reperfusion. Cardioprotective actions of E-type prostaglandins may be mediated by this receptor subtype.

Published
2005
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