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11 results on '"Robinson, Richard B."'

1. Ca 2+ -Stimulated Adenylyl Cyclase AC1 Generates Efficient Biological Pacing as Single Gene Therapy and in Combination With HCN2

Author

Boink, Gerard J.J., primary, Nearing, Bruce D., additional, Shlapakova, Iryna N., additional, Duan, Lian, additional, Kryukova, Yelena, additional, Bobkov, Yevgeniy, additional, Tan, Hanno L., additional, Cohen, Ira S., additional, Danilo, Peter, additional, Robinson, Richard B., additional, Verrier, Richard L., additional, and Rosen, Michael R., additional

Published
2012
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3. Epicardial Border Zone Overexpression of Skeletal Muscle Sodium Channel SkM1 Normalizes Activation, Preserves Conduction, and Suppresses Ventricular Arrhythmia

Author

Lau, David H., primary, Clausen, Chris, additional, Sosunov, Eugene A., additional, Shlapakova, Iryna N., additional, Anyukhovsky, Evgeny P., additional, Danilo, Peter, additional, Rosen, Tove S., additional, Kelly, Caitlin, additional, Duffy, Heather S., additional, Szabolcs, Matthias J., additional, Chen, Ming, additional, Robinson, Richard B., additional, Lu, Jia, additional, Kumari, Sinhu, additional, Cohen, Ira S., additional, and Rosen, Michael R., additional

Published
2009
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4. Xenografted Adult Human Mesenchymal Stem Cells Provide a Platform for Sustained Biological Pacemaker Function in Canine Heart

Author

Plotnikov, Alexei N., primary, Shlapakova, Iryna, additional, Szabolcs, Matthias J., additional, Danilo, Peter, additional, Lorell, Beverly H., additional, Potapova, Irina A., additional, Lu, Zhongju, additional, Rosen, Amy B., additional, Mathias, Richard T., additional, Brink, Peter R., additional, Robinson, Richard B., additional, Cohen, Ira S., additional, and Rosen, Michael R., additional

Published
2007
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5. Wild-Type and Mutant HCN Channels in a Tandem Biological-Electronic Cardiac Pacemaker

Author

Bucchi, Annalisa, primary, Plotnikov, Alexei N., additional, Shlapakova, Iryna, additional, Danilo, Peter, additional, Kryukova, Yelena, additional, Qu, Jihong, additional, Lu, Zhongju, additional, Liu, Huilin, additional, Pan, Zongming, additional, Potapova, Irina, additional, Knight, Bruce Ken, additional, Girouard, Steven, additional, Cohen, Ira S., additional, Brink, Peter R., additional, Robinson, Richard B., additional, and Rosen, Michael R., additional

Published
2006
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7. Biological Pacemaker Implanted in Canine Left Bundle Branch Provides Ventricular Escape Rhythms That Have Physiologically Acceptable Rates

Author

Plotnikov, Alexei N., primary, Sosunov, Eugene A., additional, Qu, Jihong, additional, Shlapakova, Iryna N., additional, Anyukhovsky, Evgeny P., additional, Liu, Lili, additional, Janse, Michiel J., additional, Brink, Peter R., additional, Cohen, Ira S., additional, Robinson, Richard B., additional, Danilo, Peter, additional, and Rosen, Michael R., additional

Published
2004
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11. Ca(2+)-stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2.

Author

Boink GJ, Nearing BD, Shlapakova IN, Duan L, Kryukova Y, Bobkov Y, Tan HL, Cohen IS, Danilo P Jr, Robinson RB, Verrier RL, and Rosen MR

Subjects
Adenoviridae genetics, Animals, Atrioventricular Block etiology, Benzazepines pharmacology, Catheter Ablation adverse effects, Circadian Rhythm physiology, Dogs, Electrocardiography, Gene Transfer Techniques, Heart Rate drug effects, Heart Rate physiology, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels, Ivabradine, Models, Animal, Potassium Channel Blockers pharmacology, Adenylyl Cyclases genetics, Adenylyl Cyclases physiology, Atrioventricular Block therapy, Genetic Therapy, Heart Conduction System physiology, Ion Channels genetics, Ion Channels physiology
Abstract

Background: Biological pacing performed solely via HCN2 gene transfer in vivo results in relatively slow idioventricular rates and only moderate autonomic responsiveness. We induced biological pacing using the Ca(2+)-stimulated adenylyl cyclase AC1 gene expressed alone or in combination with HCN2 and compared outcomes with those with single-gene HCN2 transfer., Methods and Results: We implanted adenoviral HCN2, AC1, or HCN2/AC1 constructs into the left bundle branches of atrioventricular-blocked dogs. During steady-state gene expression (days 5-7), differences between AC1, HCN2/AC1, and HCN2 alone were evident in basal beating rate, escape time, and dependence on electronic backup pacing. In HCN2, AC1, and HCN2/AC1, these parameters were as follows: basal beating rate: 50±1.5, 60±5.0, and 129±28.9 bpm (P<0.05 for HCN2/AC1 versus HCN2 or AC1 alone), respectively; escape time: 2.4±0.2, 1.3±0.2, and 1.1±.0.4 seconds (P<0.05 for AC1 and HCN2/AC1 versus HCN2); and percent electronic beats: 34±8%, 2±1%, and 6±2% (P<0.05 for AC1 and HCN2/AC1 versus HCN2). Instantaneous (SD1) and long-term (SD2) heart rate variability and circadian rhythm analyzed via 24-hour Holter recordings showed a shift toward greater sensitivity to parasympathetic modulation in animals injected with AC1 and a high degree of sympathetic modulation in animals injected with HCN2/AC1., Conclusion: AC1 or HCN2/AC1 overexpression in left bundle branches provides highly efficient biological pacing and greater sensitivity to autonomic modulation than HCN2 alone.

Published
2012
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