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Introduction: Myocardial injury is common after out-of-hospital-cardiac arrest (OHCA). However, little is known about the role of early serial hs-TnT in patients with OHCA for identifying myocardial injury, and whether the prevalence and severity of injury differs according to cardiac (CV) vs noncardiac (non-CV) cause of OHCA. Hypothesis: Early hs-TnT will demonstrate high rates of myocardial injury after OHCA regardless of etiology. However, in the first 6 hours after OHCA the extent of hs-TnT elevation and rate of rise will be higher in patients with CV vs non-CV etiology. Methods: Multicenter retrospective study including OHCA patients presenting from 4/1/2018 to 4/1/2019. Hs-TnT was drawn as part of routine clinical care. Results: Baseline hs-TnT was measured in 120 patients after OHCA due to CV (n=51) and non-CV (n=69) etiologies, with subsequent serial hs-TnT values at 1hr, 3hrs, and 6hrs. Hs-TnT was greater than the 99 th percentile in 97% (115/120) of patients and myocardial injury (hs-TnT> 52ng/L) was detected in 88% (105/120) of patients (no difference between CV vs non-CV etiology). Median hs-TnT values were compared between CV and non-CV etiologies of OHCA identifying no difference in hs-TnT at baseline (Figure: 54 [IQR 18-134] vs. 41 [IQR 19-100]; p=0.357) but significantly higher hs-TnT in patients with CV etiology at 1hr (159 [IQR 80-392] vs 93 [IQR 42-247]; p=0.049), 3hrs (400 [IQR 168-1005] vs 151 [IQR 75-401] p=0.009), and 6hrs (746 [IQR 248-1965] vs 251 [IQR 75-580]; p=0.001). Additionally, hs-TnT rise from baseline was present in both CV and non-CV etiologies but was significantly higher in patients with CV etiology (p = 0.005). Conclusions: As identified by hs-TnT, myocardial injury was prevalent in patients with both CV and non-CV cause of OHCA. Baseline hs-TnT was no different in patients with CV vs non-CV cause, however, over the first 6 hours both absolute value and rate of hs-TnT rise were significantly higher for patients with CV vs non-CV etiology of OHCA.

Introduction: Head computed tomography (CT) is frequently performed in survivors of out-of-hospital cardiac arrest (OHCA). However, the clinical utility of routine, early head CT in these patients is not well understood. We sought to characterize the associations between findings on early head CT with presenting characteristics and outcomes in survivors of OHCA. Hypothesis: Presence of early intracranial swelling is associated with poor outcomes. Methods: This is a retrospective analysis from a multicenter cohort of 432 patients with non-traumatic OHCA between 2/1/17 through 4/1/19. Patients were included if they underwent head CT Result: Early head CT ( Conclusions: In survivors of non-traumatic OHCA, routine, early (

Introduction: The role of cardiac biomarkers in patients after out-of-hospital cardiac arrest (OHCA) has been subject to recent research due to myocardial stress and injury associated with cardiac arrest. However, it remains unclear to what extent NT-proBNP can be used as a prognostic tool after OHCA. Hypothesis: Baseline NT-proBNP is an independent predictor of mortality in patients after OHCA. Methods: Multicenter retrospective observational cohort study including non-traumatic OHCA patients presenting from 2/1/2017 to 4/1/2019. Relationship between NT-proBNP quartiles and mortality was assessed through unadjusted and adjusted (age, gender, presenting rhythm) analyses with logistic regression. Results: Baseline NT-proBNP values were obtained for 283 patients on presentation after OHCA with median 965 pg/mL (IQR 157-3550). Levels did not differ by arrest etiology (cardiac vs noncardiac) or presenting rhythm. NT-proBNP levels correlated with age (r = 0.44, p Conclusion: In this multicenter cohort of patients with shockable and nonshockable OHCA, increased levels of NT-proBNP were predictive of an increased risk of in-hospital mortality even after adjustment for age, gender, and presenting rhythm.