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Your search keyword '"Quarck, Rozenn"' showing total 9 results
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9 results on '"Quarck, Rozenn"'

1. Worldwide CTEPH Registry: Long-Term Outcomes With Pulmonary Endarterectomy, Balloon Pulmonary Angioplasty, and Medical Therapy

Author

Delcroix, Marion, Pepke-Zaba, Joanna, D’Armini, Andrea M., Fadel, Elie, Guth, Stefan, Hoole, Stephen P., Jenkins, David P., Kiely, David G., Kim, Nick H., Madani, Michael M., Matsubara, Hiromi, Nakayama, Kazuhiko, Ogawa, Aiko, Ota-Arakaki, Jaquelina S., Quarck, Rozenn, Sadushi-Kolici, Roela, Simonneau, Gérald, Wiedenroth, Christoph B., Yildizeli, Bedrettin, Mayer, Eckhard, and Lang, Irene M.

Published
2024
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4. Role for Telomerase in Pulmonary Hypertension

Author

Mouraret, Nathalie, primary, Houssaïni, Amal, additional, Abid, Shariq, additional, Quarck, Rozenn, additional, Marcos, Elisabeth, additional, Parpaleix, Aurelien, additional, Gary-Bobo, Guillaume, additional, Dubois-Randé, Jean-Luc, additional, Derumeaux, Geneviève, additional, Boczkowski, Jorge, additional, Delcroix, Marion, additional, Blasco, Maria A., additional, Lipskaia, Larissa, additional, Amsellem, Valérie, additional, and Adnot, Serge, additional

Published
2015
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5. CCR5 as a Treatment Target in Pulmonary Arterial Hypertension

Author

Amsellem, Valérie, primary, Lipskaia, Larissa, additional, Abid, Shariq, additional, Poupel, Lucie, additional, Houssaini, Amal, additional, Quarck, Rozenn, additional, Marcos, Elisabeth, additional, Mouraret, Nathalie, additional, Parpaleix, Aurélien, additional, Bobe, Régis, additional, Gary-Bobo, Guillaume, additional, Saker, Mirna, additional, Dubois-Randé, Jean-Luc, additional, Gladwin, Mark T., additional, Norris, Karen A., additional, Delcroix, Marion, additional, Combadière, Christophe, additional, and Adnot, Serge, additional

Published
2014
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6. Weight Loss–Associated Induction of Peroxisome Proliferator–Activated Receptor-α and Peroxisome Proliferator–Activated Receptor-γ Correlate With Reduced Atherosclerosis and Improved Cardiovascular Function in Obese Insulin-Resistant Mice

Author

Verreth, Wim, primary, De Keyzer, Dieuwke, additional, Pelat, Michel, additional, Verhamme, Peter, additional, Ganame, Javier, additional, Bielicki, John K., additional, Mertens, Ann, additional, Quarck, Rozenn, additional, Benhabilès, Nora, additional, Marguerie, Gérard, additional, Mackness, Bharti, additional, Mackness, Mike, additional, Ninio, Ewa, additional, Herregods, Marie-Christine, additional, Balligand, Jean-Luc, additional, and Holvoet, Paul, additional

Published
2004
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7. Increased Low-Density Lipoprotein Oxidation and Impaired High-Density Lipoprotein Antioxidant Defense Are Associated With Increased Macrophage Homing and Atherosclerosis in Dyslipidemic Obese Mice

Author

Mertens, Ann, primary, Verhamme, Peter, additional, Bielicki, John K., additional, Phillips, Michael C., additional, Quarck, Rozenn, additional, Verreth, Wim, additional, Stengel, Dominique, additional, Ninio, Ewa, additional, Navab, Mohamad, additional, Mackness, Bharti, additional, Mackness, Mike, additional, and Holvoet, Paul, additional

Published
2003
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8. Adenovirus-Mediated Gene Transfer of Human Platelet-Activating Factor–Acetylhydrolase Prevents Injury-Induced Neointima Formation and Reduces Spontaneous Atherosclerosis in Apolipoprotein E–Deficient Mice

Author

Quarck, Rozenn, primary, De Geest, Bart, additional, Stengel, Dominique, additional, Mertens, Ann, additional, Lox, Marleen, additional, Theilmeier, Gregor, additional, Michiels, Carine, additional, Raes, Martine, additional, Bult, Hidde, additional, Collen, Désiré, additional, Van Veldhoven, Paul, additional, Ninio, Ewa, additional, and Holvoet, Paul, additional

Published
2001
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9. Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice.

Author

Verreth W, De Keyzer D, Pelat M, Verhamme P, Ganame J, Bielicki JK, Mertens A, Quarck R, Benhabilès N, Marguerie G, Mackness B, Mackness M, Ninio E, Herregods MC, Balligand JL, and Holvoet P

Subjects
Adipose Tissue metabolism, Adipose Tissue pathology, Animals, Aorta, Thoracic metabolism, Arteriosclerosis etiology, Arteriosclerosis genetics, Arteriosclerosis metabolism, Autoantibodies analysis, Circadian Rhythm, Echocardiography, Genotype, Glucose metabolism, Heart Function Tests, Hypertriglyceridemia etiology, Hypertriglyceridemia prevention & control, Inflammation, Leptin deficiency, Leptin genetics, Lipoproteins, LDL analysis, Lipoproteins, LDL immunology, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Obese, Myocardium metabolism, Obesity complications, Obesity genetics, Obesity pathology, Oxidative Stress, PPAR alpha genetics, PPAR gamma genetics, Receptors, LDL deficiency, Receptors, LDL genetics, Transcription, Genetic, Arteriosclerosis prevention & control, Gene Expression Regulation physiology, Insulin Resistance, Obesity diet therapy, PPAR alpha biosynthesis, PPAR gamma biosynthesis, Up-Regulation, Weight Loss
Abstract

Background: Weight loss in obese insulin-resistant but not in insulin-sensitive persons reduces coronary heart disease risk. To what extent changes in gene expression are related to atherosclerosis and cardiovascular function is unknown., Methods and Results: We studied the effect of diet restriction-induced weight loss on gene expression in the adipose tissue, the heart, and the aortic arch and on atherosclerosis and cardiovascular function in mice with combined leptin and LDL-receptor deficiency. Obesity, hypertriglyceridemia, and insulin resistance are associated with hypertension, impaired left ventricular function, and accelerated atherosclerosis in those mice. Compared with lean mice, peroxisome proliferator-activated receptors (PPAR)-alpha and PPAR-gamma expression was downregulated in obese double-knockout mice. Diet restriction caused a 45% weight loss, an upregulation of PPAR-alpha and PPAR-gamma, and a change in the expression of genes regulating glucose transport and insulin sensitivity, lipid metabolism, oxidative stress, and inflammation, most of which are under the transcriptional control of these PPARs. Changes in gene expression were associated with increased insulin sensitivity, decreased hypertriglyceridemia, reduced mean 24-hour blood pressure and heart rate, restored circadian variations of blood pressure and heart rate, increased ejection fraction, and reduced atherosclerosis. PPAR-alpha and PPAR-gamma expression was inversely related to plaque volume and to oxidized LDL content in the plaques., Conclusions: Induction of PPAR-alpha and PPAR-gamma in adipose tissue, heart, and aortic arch is a key mechanism for reducing atherosclerosis and improving cardiovascular function resulting from weight loss. Improved lipid metabolism and insulin signaling is associated with decreased tissue deposition of oxidized LDL that increases cardiovascular risk in persons with the metabolic syndrome.

Published
2004
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