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We read with great interest the article by Wiberg et al1 that was recently published in Circulation . The authors conducted a randomized double-blind clinical trial to demonstrate the neuroprotective effect of the glucagon-like peptide-1 analog exenatide by acute administration of exenatide to comatose patients in the intensive care unit after out-of-hospital cardiac arrest. However, exenatide failed to reduce neuron-specific enolase levels and did not significantly improve a composite end point of death and neurological function in adults with out-of-hospital cardiac arrest. The negative …

We congratulate Smolderen et al for their significant work recently published in Circulation about the effects of antidepression therapy in patients hospitalized with a first acute myocardial infarction.1 The findings of this observational multicenter cohort study indicate that antidepressant therapy appears to fail to improve the adjusted 1-year risk of mortality for depressed patients after …

We read with great interest the article by Hahn et al1 that was published recently in Circulation . The authors conducted a large-scale study to demonstrate cardioprotective effect by ischemic postconditioning at the target lesion in patients with ST-segment–elevation myocardial infarction undergoing percutaneous coronary intervention. However, postconditioning failed to improve myocardial reperfusion in patients with ST-segment–elevation myocardial infarction undergoing primary percutaneous coronary intervention with standard practice. Postconditioning is still in early stages of development, and clinical implications remain to be established as stated …