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We read with great interest the case presented by Fiol-Sala and Bayes de Luna1 about identification of lesion location in acute anterior myocardial infarction. In this case, the authors proposed that if it were proximal occlusion of the long left anterior descending artery (LAD), then …

We read with great interest the article by Saleheen et al1 about the interaction of smoking behavior with genotypes associated with coronary heart disease (CHD) risk, which indicates that reduced ADAMTS7 expression confers stronger CHD protection in never-smokers than in ever-smokers, and increased …

We read with great interest the case presented by Robert and colleagues1 about pulseless electric activity (PEA) that shows the importance of interpreting the ECG and finding the cause of PEA in cardiopulmonary resuscitation. We have 2 questions about this case. First, PEA can be the result of a wide spectrum …

We read with great interest the case presented by Beach and colleagues1 of idiopathic ventricular fibrillation in a 29-year-old man. This is an excellent case of the management of sudden cardiac arrest in the young. We have several questions and suggestions. First, all the triggering premature ventricular contractions have a left bundle-branch block morphology with a superior axis and a late R:S transition point at …

We read with great interest the article by Yamagata et al1 about the genotype-phenotype correlation of SCN5A mutations for the clinical and electrocardiographic characteristics of probands with Brugada syndrome, which indicates that patients with Brugada syndrome with SCN5A mutations exhibit more conduction abnormalities on ECG and have a higher risk for cardiac events. This study has a …

We read with great interest the article by Hoffmann and colleagues1 about the prognostic value of noninvasive cardiovascular testing in patients with stable chest pain. The article indicates that coronary computed tomography angiography (CTA) provides better prognostic information than functional testing in contemporary patients who have stable chest pain with a low burden of obstructive coronary artery disease, myocardial ischemia, and events. CTA operates by identifying patients …

We read with great interest the article by Shimura et al1 about the prognostic impact of the Clinical Frailty Scale (CFS) on outcomes after transcatheter aortic valve replacement, which indicates that in addition to reflecting the degree of frailty and showing significant correlation with body mass index, albumin, gait speed, and grip strength, the CFS is a useful marker for predicting late mortality in an elderly transcatheter aortic valve replacement cohort. Attracted by the simple and useful characteristic of this tool, …

We read with great interest the article by Young et al1 on the impact of pioglitazone on acute coronary events that indicates that pioglitazone decreases the risk of acute coronary syndrome by 29%, specifically in the reduction of the risk of type 1 myocardial infarctions (spontaneous myocardial infarctions). This is an excellent work on the cardiovascular protection of patients with insulin resistance without diabetes mellitus, but …

We read with great interest the article by Parkash et al1 about the effect of aggressive blood pressure control on the recurrence of atrial fibrillation after catheter ablation, which shows that aggressive control of blood pressure for a median duration of 3.5 months before catheter ablation and after has no effect on subsequent arrhythmia outcome at the expense of treatment-related hypotension. Does aggressive blood control have a neutral effect on the recurrence of atrial fibrillation after catheter ablation? We have several disagreements. First, before aggressive blood pressure …

We read with great interest the article by Hunter and colleagues1 on the pathogenic mechanism of cardiovascular injury in firefighters. Cardiovascular events are the main cause of deaths among firefighter and responsible for nearly 45% of on-duty fatalities each year in the United States. High temperatures, extreme physical exertion, and noxious air pollutants may contribute to the cardiovascular events. …

We read with great interest the article by Sogaard and colleagues1 about pericarditis as a marker of occult cancer. The article indicates that pericarditis may be a marker of occult lung and breast cancer, as well as hematologic and unspecified metastatic cancers, and it is associated with worse survival among …

We read with great interest the case presented by Goldwasser and colleagues1 about the lesion location of old myocardial infarction. This case clearly shows that when a broad R>S presented in V1, it indicates lateral wall myocardial infarction instead …

We read with great interest the article by Guo and colleagues1 about the cardioprotective role of tumor necrosis factor receptor-associated factor 2(TRAF2) by suppressing apoptosis and necroptosis, which indicates that TRAF2 functions as a critical prosurvival factor in …

We read with great interest the case presented by Garcia-Granja and colleagues1 about worsening conduction delay in hypertrophic cardiomyopathy when taking propafenone for atrial fibrillation. We have 3 questions about this interesting case. First, baseline ECG shows first atrioventricular block …

We read with great interest the article presented by Enrico Ammirati and colleagues1 about survival and left ventricular function changes in fulminant versus nonfulminant acute myocarditis, which indicates that subjects with a fulminant presentation have a greater rate of in-hospital death or transplantation and lower long-term survival than …

We read with great interest the article by Soliman and colleagues1 about the effect of intensive blood pressure (BP) lowering on left ventricular hypertrophy in patients with hypertension. The article indicates that intensive BP lowering results in lower rates of developing new left ventricular hypertrophy (LVH) in those without LVH and higher rates of regression of LVH in those with existing LVH …

We read with great interest the article by Aubdool and colleagues1 on the effects of a novel stable α-calcitonin gene-related peptide analogue (α-CGRP) on heart protection in angiotensin II–infused mice and a pressure-overload cardiac hypertrophy …

We read with great interest the article presented by Joseph B. Lerman and his colleagues1 about the coronary plaque characterization in psoriasis, which indicates that patients with psoriasis had a greater noncalcified coronary plaque burden and increased high-risk plaque prevalence than healthy volunteers, and the plaque conditions can improve after 1 year of …

We read with great interest the article by Kosiborod and colleagues1 about the lower risk of heart failure and death in patients initiated on sodium-glucose cotransporter-2 inhibitors(SGLT-2i) versus other glucose-lowering inhibitors (SGLT-2i) versus other glucose-lowering drugs. This large real-world study of >300 000 patients with type 2 diabetes mellitus shows …

We read with great interest the article presented by Asrress and colleagues1 about the physiology of angina and its alleviation with nitroglycerin (NTG), which characterizes intracoronary physiological behavior of coronary stenosis during exercise before and after NTG and explains the physiological consequences directly related to angina relief (reducing …

We read with great interest the article presented by Ahmed Merghani and his colleagues1 about the prevalence of subclinical coronary artery disease in masters endurance athletes with a low atherosclerotic risk, which indicates that longstanding endurance exercise may modestly increase the likelihood of developing calcified coronary …

We read with great interest the article presented by Masaru Obokata and his colleagues1 about the distinct obese phenotype of heart failure with preserved ejection fraction (HFpEF), which provides strong evidence supporting obese HFpEF as a valid HFpEF phenotype. This will help us differentiate and better understand …